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AB141408

QS11, ARFGAP1 inhibitor

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(1 Publication)

MW 567.7 Da, Purity >98%. Potent GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor (EC50 = 0.5 μM). Wnt/β-catenin pathway modulator. Antitumor agent. Active in vitro.

View Alternative Names

ADP-ribosylation factor 1, ARF1_HUMAN

1 Images
Chemical Structure - QS11, ARFGAP1 inhibitor (AB141408)
  • Chemical Structure

Lab

Chemical Structure - QS11, ARFGAP1 inhibitor (AB141408)

2D chemical structure image of ab141408, QS11, ARFGAP1 inhibitor

Key facts

CAS number

944328-88-5

Purity

>98%

Form

Solid

form

Molecular weight

567.7 Da

Molecular formula

C<sub>3</sub><sub>6</sub>H<sub>3</sub><sub>3</sub>N<sub>5</sub>O<sub>2</sub>

PubChem

42623900

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

(2S)-2-{[9-(4-Biphenylylmethyl)-2-(2,3-dihydro-1H-inden-5-yloxy)-9H-purin-6-yl]amino}-3-phenyl-1-propanol

Biological description

Potent GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor (EC50 = 0.5 μM). Wnt/β-catenin pathway modulator. Antitumor agent. Active in vitro.

Canonical smiles

C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)NC(CC7=CC=CC=C7)CO

Isomeric smiles

C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)N[C@@H](CC7=CC=CC=C7)CO

InChi

InChI=1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1

InChiKey

DOKZLKDGUQWMSX-HKBQPEDESA-N

IUPAC Name

(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1680 QS11. 1680-5 is the same size as the 5 mg size of ab141408.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARF1 also known as ADP-ribosylation factor 1 or ARF1 protein is a small GTPase with a molecular mass of approximately 20 kDa. Commonly expressed in a variety of cell types ARF1 plays a central role in vesicle trafficking. As an activator ARF1 interacts with different GTPase-activating proteins such as ARFGAP1 and BIG1 ensuring the proper distribution of proteins and lipids in cells. ARF1's expression occurs across numerous cellular compartments including the Golgi apparatus aiding in the formation of transport vesicles.
Biological function summary

ARF1 is essential in regulating membrane dynamics and vesicular traffic. It forms part of the COPI and clathrin-coated vesicle complexes where it recruits coat proteins to budding vesicles. This recruitment is fundamental for maintaining Golgi structure and function. Additionally ARF1 plays a role in cytokinesis by interacting with the septin cytoskeleton. The protein also influences actin cytoskeleton remodeling which is pivotal for cell shape changes and motility.

Pathways

ARF1 is central to both the endocytic and secretory pathways. It collaborates with proteins like ARFS and 3F1 in modulating the trafficking of cargo between the endoplasmic reticulum and Golgi. Within the secretory pathway ARF1 interacts with SNARE proteins to facilitate vesicle docking and fusion. Its actions in pathways maintain cellular homeostasis and promote proper cellular response to various stimuli.

ARF1 has links to cancer and Alzheimer's disease. Overexpression of ARF1 correlates with tumor progression and metastasis impacting cell proliferation and survival mechanisms. Additionally its disruption associates with Alzheimer's where it may influence amyloid precursor protein processing alongside interactions with GAP proteins. Understanding ARF1's role in these conditions highlights its potential as a therapeutic target stressing the importance of studying its interactions with disease-related proteins.
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 39:2048-2060 PubMed29786451

2018

Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability.

Applications

Unspecified application

Species

Unspecified reactive species

Wenlu Li,Zhigang Chen,Jing Yuan,Zhanyang Yu,Chongjie Cheng,Qiuchen Zhao,Lena Huang,Katherine A Hajjar,Zhong Chen,Eng H Lo,Haibin Dai,Xiaoying Wang
View all publications
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