MW 302.23 Da, Purity >97%. Antioxidative flavonoid. Anticancer, antithrombotic and anti-inflammatory agent. Actions include inhibition of mitochondrial ATPase, phosphodiesterases, PI3-kinase and PIP kinase activity.
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- Phytomedicine : international journal of phytother 58:1528932019Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Ju Lin et. al.PubMed 30901663
- Scientific reports 7:22622017Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaoru Ishida et. al.PubMed 28536445
Key facts
- CAS number
- 117-39-5
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 302.23 Da
- Molecular formula
- C15H10O7
- PubChem identifier
- 5280343
- Nature
- Synthetic
Target data
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MW 302.23 Da, Purity >97%. Antioxidative flavonoid. Anticancer, antithrombotic and anti-inflammatory agent. Actions include inhibition of mitochondrial ATPase, phosphodiesterases, PI3-kinase and PIP kinase activity.
Key facts
- CAS number
- 117-39-5
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 302.23 Da
- Molecular formula
- C15H10O7
- PubChem identifier
- 5280343
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Quercetin
- Biological description
Antioxidative flavonoid. Anticancer, antithrombotic and anti-inflammatory agent. Actions include inhibition of mitochondrial ATPase, phosphodiesterases, PI3-kinase and PIP kinase activity.
- Canonical SMILES
- C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
- InChI
- InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
- InChIKey
- REFJWTPEDVJJIY-UHFFFAOYSA-N
- IUPAC name
- 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Quercetin, Antioxidative flavonoid (ab120247)
2D chemical structure image of ab120247, Quercetin, Antioxidative flavonoid
Functional Studies - Quercetin, Antioxidative flavonoid (ab120247)
Anti-Caspase-3 antibody ab13847 staining active caspase 3 in A549 cells treated with quercetin (ab120247), by ICC/IF. Increase in active caspase 3 expression correlates with increased concentration of quercetin, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120247 (quercetin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-Caspase-3 antibody ab13847 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab968999) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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