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AB141247

Quinine, Potassium channel blocker

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(1 Publication)

MW 324.42 g/mol, Purity >98%. Potassium channel blocker. Blocks small conductance Ca2+ -activated K+ channels. Inhibits TRPM7 currents. Shows antipyretic, antimalarial, analgesic, anti-inflammatory and anticonvulsant effects in vivo. Orally active.
1 Images
Chemical Structure - Quinine, Potassium channel blocker (AB141247)
  • Chemical Structure

Lab

Chemical Structure - Quinine, Potassium channel blocker (AB141247)

2D chemical structure image of ab141247, Quinine, Potassium channel blocker

Key facts

CAS number

130-95-0

Purity

>98%

Form

Solid

form

Molecular weight

324.42 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>4</sub>N<sub>2</sub>O<sub>2</sub>

Nature

Synthetic

Biological description

Potassium channel blocker. Blocks small conductance Ca2+ -activated K+ channels. Inhibits TRPM7 currents. Shows antipyretic, antimalarial, analgesic, anti-inflammatory and anticonvulsant effects in vivo. Orally active.

Isomeric smiles

CL.COC1CC2C(CC1)NCCC2[C@@H](O)C4CC3CCN4C[C@@H]3C=C

InChi

InChI=1S/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14?,19?,20+;/m0./s1

InChiKey

LBSFSRMTJJPTCW-ORYHUWJNSA-N

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

FEBS letters 595:2437-2446 PubMed34387857

2021

K regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Ileana Cristea,Ove Bruland,Eyvind Rødahl,Cecilie Bredrup
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Product promise

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