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MW 243.28 Da, Purity >99%. Selective antitumor agent. Active against colon, renal and breast carcinomas in vitro and ex vivo. Inhibits thioredoxin reductase with potencies correlated with antiproliferative and cytotoxic effects. Potent inhibitory effect in NCI 60 cells (GI50 =0.23 μM and LC50 = 3.39 μM).

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Images

Chemical Structure - Quinol 2, Antitumor agent (AB144640), expandable thumbnail

Key facts

CAS number
485842-97-5
Purity
> 99%
Form
Solid
Molecular weight
243.28 Da
Molecular formula
C13H9NO2S
PubChem identifier
482697
Nature
Synthetic

Target data

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MW 243.28 Da, Purity >99%. Selective antitumor agent. Active against colon, renal and breast carcinomas in vitro and ex vivo. Inhibits thioredoxin reductase with potencies correlated with antiproliferative and cytotoxic effects. Potent inhibitory effect in NCI 60 cells (GI50 =0.23 μM and LC50 = 3.39 μM).

Key facts

Purity
> 99%
PubChem identifier
482697
Solubility

Soluble in ethanol to 100 mM.

Soluble in DMSO to 100 mM.

Biochemical name
4-(Benzothiazol-2-yl)-4-hydroxy-2,5-cyclohexadien-1-one
Biological description

Selective antitumor agent. Active against colon, renal and breast carcinomas in vitro and ex vivo. Inhibits thioredoxin reductase with potencies correlated with antiproliferative and cytotoxic effects. Potent inhibitory effect in NCI 60 cells (GI50 =0.23 μM and LC50 = 3.39 μM).

Canonical SMILES
C1=CC=C2C(=C1)N=C(S2)C3(C=CC(=O)C=C3)O
InChI
InChI=1S/C13H9NO2S/c15-9-5-7-13(16,8-6-9)12-14-10-3-1-2-4-11(10)17-12/h1-8,16H
InChIKey
SDYBYKXWYDVVKP-UHFFFAOYSA-N
IUPAC name
4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

Sold under license from CRT.

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1 product image

  • Chemical Structure - Quinol 2, Antitumor agent (ab144640), expandable thumbnail

    Chemical Structure - Quinol 2, Antitumor agent (ab144640)

    2D chemical structure image of ab144640, Quinol 2, Antitumor agent

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Product protocols

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