AB120117

QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

Name: QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (CAS 21306-56-9) | Abcam
Brand: Abcam Limited
SKU: AB120117
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(14 Publications)

MW 343.3 Da, Purity >99%. A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.

View Alternative Names

ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, Acetylcholine receptor muscarinic 5, CHKM5MR, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, HM 4, HM 5, M4, M5R, MGC41838, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, m5

1 Images

Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

Chemical Structure

Lab

Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

2D chemical structure image of ab120117, QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

Key facts

CAS number

21306-56-9

Purity

>99%

Form

Solid

form

Molecular weight

343.3 Da

Molecular formula

C16H27BrN2O

PubChem

9884487

Nature

Synthetic

Biochemical name

Lidocaine N-ethyl bromide

Biological description

A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]

InChi

InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChiKey

DLHMKHREUTXMCH-UHFFFAOYSA-N

IUPAC Name

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromide

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Muscarinic acetylcholine receptors M4 (CHRM4) and M5 (CHRM5) are types of G protein-coupled receptors (GPCRs) that interact with the neurotransmitter acetylcholine. CHRM4 has a molecular mass around 49 kDa while CHRM5's mass is approximately 53 kDa. CHRM4 is expressed in areas like the cortex hippocampus and striatum while CHRM5 is found in regions like the basal forebrain and the thalamus. These receptors mediate different physiological responses through the modulation of intracellular signaling pathways.

Biological function summary

Muscarinic acetylcholine receptors are critical in regulating functions such as cognitive processing motor control and autonomic nervous system actions. They do not operate as part of a multi-protein complex but engage in signaling mechanisms after neurotransmitter binding. Both receptor types contribute to neural circuitry by activating phosphoinositide breakdown and modulating cyclic AMP levels.

Pathways

Muscarinic acetylcholine receptors participate in the cholinergic signaling pathway. This pathway is essential for neurotransmission in the central and peripheral nervous systems. Interaction with G proteins particularly Gi/o for CHRM4 and Gq/11 for CHRM5 allows these receptors to influence downstream effectors like phospholipase C. Other proteins related to this pathway include the nicotinic acetylcholine receptors that also bind acetylcholine to propagate neural signals.

Muscarinic acetylcholine receptors are linked to conditions like schizophrenia and Alzheimer's disease. CHRM4 appears connected to schizophrenia likely due to its role in modulating dopaminergic and glutamatergic neurotransmission. CHRM5 through its signaling pathways relates to Alzheimer’s impacting cognitive functions. Both receptors maintain interactions with proteins like the NMDA receptor in the context of these disorders influencing their pathophysiological roles.

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Product protocols

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:3949-3969 PubMed37037606

2023

Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Xi,Si-Qing Cai,Hui-Fang Yan,Yue Tian,Jie Cai,Xiao-Mei Yang,Jing-Min Wang,Guo-Gang Xing

Cell 172:1108-1121.e15 PubMed29474910

2018

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Tønnesen,V V G Krishna Inavalli,U Valentin Nägerl

Neuron 95:1306-1318.e5 PubMed28910619

2017

Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Yuan Chu,Eileen L McIver,Ryan F Kovaleski,Jeremy F Atherton,Mark D Bevan

Cerebral cortex (New York, N.Y. : 1991) 26:2715-27 PubMed26045570

2015

Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Tsan-Ting Hsu,Cheng-Ta Lee,Ming-Hong Tai,Cheng-Chang Lien

Nature neuroscience 18:674-82 PubMed25821912

2015

GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.

Applications

Unspecified application

Species

Unspecified reactive species

Marzieh Zonouzi,Joseph Scafidi,Peijun Li,Brian McEllin,Jorge Edwards,Jeffrey L Dupree,Lloyd Harvey,Dandan Sun,Christian A Hübner,Stuart G Cull-Candy,Mark Farrant,Vittorio Gallo

Proceedings of the National Academy of Sciences of 110:15800-5 PubMed24019494

2013

Presynaptic gating of excitation in the dorsal raphe nucleus by GABA.

Applications

Unspecified application

Species

Unspecified reactive species

Mariano Soiza-Reilly,Wayne B Anderson,Christopher W Vaughan,Kathryn G Commons

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:5486-98 PubMed23536064

2013

Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Giulia Quattrocolo,Gianmaria Maccaferri

Journal of neurophysiology 109:2712-9 PubMed23515792

2013

Serotonergic modulation of neuronal activity in rat midbrain periaqueductal gray.

Applications

Unspecified application

Species

Unspecified reactive species

Hyo-Jin Jeong,Karen Lam,Vanessa A Mitchell,Christopher W Vaughan

Journal of neurophysiology 109:1704-12 PubMed23303863

2013

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.

Applications

Unspecified application

Species

Unspecified reactive species

Michelino Puopolo,Alexander M Binshtok,Gui-Lan Yao,Seog Bae Oh,Clifford J Woolf,Bruce P Bean

BMC neuroscience 13:14 PubMed22276909

2012

Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Ilse Riebe,Eric Hanse

View all publications

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QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Publications (14)

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