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AB144493

QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker

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(4 Publications)

MW 298.8 Da, Purity >99%. A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels. Soluble in 1 ml water to give specified mM/ml concentration.
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Chemical Structure - QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker (AB144493)
  • Chemical Structure

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Chemical Structure - QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker (AB144493)

2D chemical structure image of ab144493, QX-314 chloride (N-Ethyllidocaine chloride) (mM/ml), Na+ channel blocker

Key facts

CAS number

5369-03-9

Purity

>99%

Form

Solid

form

Molecular weight

298.8 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>7</sub>ClN<sub>2</sub>O

PubChem

21462

Nature

Synthetic

Biochemical name

QX 314 chloride

Biological description

A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]

InChi

InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChiKey

LLPPOMUAOGMYQI-UHFFFAOYSA-N

IUPAC Name

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;chloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:9259-72 PubMed23719795

2013

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Tamara Perez-Rosello,Charles T Anderson,Francisco J Schopfer,Yanjun Zhao,David Gilad,Sonia R Salvatore,Bruce A Freeman,Michal Hershfinkel,Elias Aizenman,Thanos Tzounopoulos

Journal of neurophysiology 106:2570-9 PubMed21832038

2011

Pre- and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel T Case,Deda C Gillespie

Neuron 71:180-94 PubMed21745647

2011

Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission.

Applications

Unspecified application

Species

Unspecified reactive species

Martha W Bagnall,Court Hull,Eric A Bushong,Mark H Ellisman,Massimo Scanziani

Neuropsychopharmacology : official publication of 36:1801-10 PubMed21525858

2011

Cholecystokinin exerts an effect via the endocannabinoid system to inhibit GABAergic transmission in midbrain periaqueductal gray.

Applications

Unspecified application

Species

Unspecified reactive species

Vanessa A Mitchell,Hyo-Jin Jeong,Geoffrey M Drew,Christopher W Vaughan
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