JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB273389

R 7050

Be the first to review this product! Submit a review

|

(0 Publication)

MW 380.8 Da, Purity >99%. Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.
1 Images
Chemical Structure - R 7050 (AB273389)
  • Chemical Structure

Lab

Chemical Structure - R 7050 (AB273389)

Chemical structure of R 7050, 303997-35-5

Key facts

CAS number

303997-35-5

Purity

>99%

Form

Solid

form

Molecular weight

380.8 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>8</sub>ClF<sub>3</sub>N<sub>4</sub>S

PubChem

1486608

Nature

Synthetic

Solubility

Soluble in dimethyl formamide to 25 mM

Biochemical name

8-Chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Biological description

Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.

Canonical smiles

C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F

InChi

InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H

InChiKey

SUUMKHOVGVYGOP-UHFFFAOYSA-N

IUPAC Name

8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB229050

Anti-XIAP antibody [EPR22189-113]

RabMAb|Recombinant|KO Validated

Western blot - Anti-XIAP antibody [EPR22189-113] (AB229050)

  • 0
  • 0
Primary Antibodies

AB220163

Anti-YTHDF2 antibody [EPR20318]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-YTHDF2 antibody [EPR20318] (AB220163)

  • 5
  • 3
Primary Antibodies

AB131281

Anti-Exportin-5 antibody [EPR8453]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Exportin-5 antibody [EPR8453] (AB131281)

  • 4
  • 1
Primary Antibodies

AB109234

Anti-Vitamin D Receptor antibody [EPR4552] - ChIP Grade

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-Vitamin D Receptor antibody [EPR4552] - ChIP Grade (AB109234)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com