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MW 380.8 Da, Purity >99%. Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.

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Images

Chemical Structure - R 7050 (AB273389), expandable thumbnail

Key facts

CAS number
303997-35-5
Purity
> 99%
Form
Solid
Molecular weight
380.8 Da
Molecular formula
C16H8ClF3N4S
PubChem identifier
1486608
Nature
Synthetic

Target data

Recommended products

MW 380.8 Da, Purity >99%. Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.

Key facts

Purity
> 99%
PubChem identifier
1486608
Solubility

Soluble in dimethyl formamide to 25 mM.

Biochemical name
8-Chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Biological description

Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.

Canonical SMILES
C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F
InChI
InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
InChIKey
SUUMKHOVGVYGOP-UHFFFAOYSA-N
IUPAC name
8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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1 product image

  • Chemical Structure - R 7050 (ab273389), expandable thumbnail

    Chemical Structure - R 7050 (ab273389)

    Chemical structure of R 7050, 303997-35-5

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Product protocols

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