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AB120604

(R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor

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(3 Publications)

MW 223.74 Da, Purity >99%. Selective and irreversible MAO-B inhibitor (IC50 = 6.8 nM). Elicits neuroprotective and neuronal rescue activity. Alleviates oxidative stress.
2 Images
Immunocytochemistry/ Immunofluorescence - (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor (AB120604)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor (AB120604)

ab692 staining Bcl2 in SK-N-SH cells treated with (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) (ab120604), by ICC/IF. Increase of Bcl2 expression correlates with increased concentration of (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120604 ((R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab692 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor (AB120604)
  • Chemical Structure

Lab

Chemical Structure - (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor (AB120604)

2D chemical structure image of ab120604, (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor

Key facts

CAS number

14611-52-0

Purity

>99%

Form

Solid

form

Molecular weight

223.74 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>8</sub>ClN

PubChem

26758

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Selegiline hydrochloride

Biological description

Selective and irreversible MAO-B inhibitor (IC50 = 6.8 nM). Elicits neuroprotective and neuronal rescue activity. Alleviates oxidative stress.

Canonical smiles

CC(CC1=CC=CC=C1)N(C)CC#C.Cl

Isomeric smiles

C[C@H](CC1=CC=CC=C1)N(C)CC#C.Cl

InChi

InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

InChiKey

IYETZZCWLLUHIJ-UTONKHPSSA-N

IUPAC Name

(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecules (Basel, Switzerland) 24: PubMed31694262

2019

Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Wang,Ren-Yuan Hong,Mengyao Guo,Yi Liu,Nianhang Chen,Xun Li,De-Xin Kong

Acta neuropathologica communications 6:120 PubMed30409187

2018

Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.

Applications

Unspecified application

Species

Unspecified reactive species

Justin W Nicholatos,Adam B Francisco,Carolyn A Bender,Tiffany Yeh,Fraz J Lugay,Jairo E Salazar,Christin Glorioso,Sergiy Libert

Biomedicine & pharmacotherapy = Biomedecine & phar 103:680-690 PubMed29679909

2018

Mechanisms of the active components from Korean pine nut preventing and treating d-galactose-induced aging rats.

Applications

Unspecified application

Species

Unspecified reactive species

Jianmei Zhang,Weiwei Lin,Ruijun Wu,Yanmeng Liu,Kai Zhu,Jinyu Ren,Sufang Zhang,Xiaomei Ling
View all publications
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