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AB145200

R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor

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MW 399.3 Da, Purity >98%. Selective K+/Cl--cotransporter inhibitor. Does not affect the bumetanide-sensitive Na+/K+/Cl--cotransport system. Suppresses osteoclastic pit formation and Cl- and H+ extrusion.
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Chemical Structure - R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor (AB145200)
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Chemical Structure - R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor (AB145200)

2D chemical structure image of ab145200, R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor

Key facts

CAS number

81166-47-4

Purity

>98%

Molecular weight

399.3 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>4</sub>Cl<sub>2</sub>O<sub>4</sub>

PubChem

10386195

Nature

Synthetic

Solubility

Soluble in ethanol

Soluble in DMSO to 50 mM

Biochemical name

R(+)-Butylindazone

Biological description

Selective K+/Cl--cotransporter inhibitor. Does not affect the bumetanide-sensitive Na+/K+/Cl--cotransport system. Suppresses osteoclastic pit formation and Cl- and H+ extrusion.

Canonical smiles

CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3

Isomeric smiles

CCCC[C@]1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3

InChi

InChI=1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1

InChiKey

YAWWQIFONIPBKT-FQEVSTJZSA-N

IUPAC Name

2-[[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl]oxy]acetic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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