(R)-(-)-Rolipram, Selective PDE4 inhibitor
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(1 Publication)
MW 275.34 Da, Purity >98%. Selective PDE4 inhibitor (IC50 = 0.22 μM). More active enantiomer: 2-10-fold more potent that the (S)-(+)-enantiomer (ab120030).
View Alternative Names
1,8-cineole 2-exo-monooxygenase, 2EL, 5''-cyclic phosphodiesterase 4A, 5''-cyclic phosphodiesterase 4B, 5''-cyclic phosphodiesterase 4C, 5''-cyclic phosphodiesterase 4D, Albendazole monooxygenase, Albendazole sulfoxidase, CBP_HUMAN, CP33, CP34, CP3A4_HUMAN, CREB-binding protein, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cyclic AMP responsive enhancer binding protein, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686F2182, DKFZp686M11213, DPDE 1, DPDE2, DPDE3, DPDE4, Dunce like phosphodiesterase E3, FLJ97311, Glucocorticoid inducible P450, HLP, HSPDE4D, KAT3A, MGC126222, MGC126529, MGC126680, NF 25, Nifedipine oxidase, OTTHUMP00000010652, OTTHUMP00000010653, OTTHUMP00000010654, OTTHUMP00000010656, OTTHUMP00000232365, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PDE 21, PDE IVB, PDE32, PDE4, PDE43, PDE46, PDE4A11, PDE4A_HUMAN, PDE4B5, PDE4B_HUMAN, PDE4C_HUMAN, PDE4DN2, PDE4D_HUMAN, Phosphodiesterase 4A, Phosphodiesterase 4A, cAMP-specific (dunce, Phosphodiesterase 4B, Phosphodiesterase 4B cAMP specific, Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila), Phosphodiesterase 4C, Phosphodiesterase 4C cAMP specific, Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila), Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3), Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila), Phosphodiesterase 4D cAMP-specific, Phosphodiesterase 4D, cAMP specific (dunce), Phosphodiesterase E1 dunce homolog, Phosphodiesterase E1 dunce homolog Drosophila, Phosphodiesterase E2 dunce homolog, Drosophila, Phosphodiesterase type 4C, Quinine 3-monooxygenase, RSTS, RTS, Rubinstein Taybi syndrome, STRK1, Taurochenodeoxycholate 6-alpha-hydroxylase, cAMP specific 3' 5' cyclic phosphodiesterase 4C, cAMP specific 3',5' cyclic phosphodiesterase 4D, cAMP specific phosphodiesterase, cAMP specific phosphodiesterase 4D, cAMP specific phosphodiesterase PDE4D6, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific phosphodiesterase-4 B isoform, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, dunce like phosphodiesterase E2, dunce-like phosphodiesterase E4, phosphodiesterase 4A cAMP specific, phosphodiesterase E2 dunce homolog, phosphodiesterase isozyme 4, phosphodiesterase type 4A11
- Chemical Structure
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Chemical Structure - (R)-(-)-Rolipram, Selective PDE4 inhibitor (AB120031)
2D chemical structure image of ab120031, (R)-(-)-Rolipram, Selective PDE4 inhibitor
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CREBBP interacts with many transcription factors and co-regulates gene expressions essential for cell growth differentiation and apoptosis. It is part of large protein complexes including the transcription machinery. CYP3A4 metabolizes a vast array of xenobiotics and endogenous compounds influencing drug clearance and metabolic activation. The PDE4 family consisting of PDE4A PDE4B PDE4C and PDE4D regulates cellular cAMP levels affecting various signaling pathways linked to inflammation and immune response.
Pathways
CREBBP participates in the chromatin remodeling and gene transcription pathways relating to proteins like p300. CYP3A4 is integral to the drug metabolism pathway closely interacting with proteins such as CYP2C9. PDE4 isoforms contribute to the cAMP signaling pathway affecting downstream proteins involved in immune and inflammatory responses. In these pathways they modulate signaling cascades important for physiological responses.
Publications (1)
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine 52:263-9 PubMed21270457
2011
Applications
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