(R)-(+)-SKF38393 hydrochloride, D1 partial agonist
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(1 Publication)
MW 291.77 Da, Purity >98%. Selective D1 receptor partial agonist. Active enantiomer of (±)-SKF-38393 (ab120740).
View Alternative Names
15-PGDH, 15-hydroxyprostaglandin dehydrogenase [NAD+], 3',5'-cyclic AMP synthetase, 70 kDa lysosomal alpha-glucosidase, A3G, ABC3G_HUMAN, AC-III, AC2, AC6, ACVI, ADCY3_HUMAN, ADCY6_HUMAN, ADCYB, APOBEC-related cytidine deaminase, APOBEC-related protein, APOBEC-related protein 9, APOBEC3G, ARCD, ARP-9, ATP pyrophosphate lyase 2, ATP pyrophosphate-lyase, ATP pyrophosphate-lyase 3, ATP pyrophosphate-lyase 6, ATP pyrophosphate-lyase 8, Acid Maltase, Acid alpha glucosidase, Adenylate cyclase, Adenylate cyclase 2, Adenylate cyclase 2 (brain), Adenylate cyclase 6, Adenylate cyclase 8, Adenylate cyclase II, Adenylate cyclase type 2, Adenylate cyclase type 3, Adenylate cyclase type 6, Adenylate cyclase type II, Adenylate cyclase type III, Adenylate cyclase type VI, Adenylate cyclase type VIII, Adenylyl cyclase 3, Adenylyl cyclase 6, Adenylyl cyclase 8 brain, Aglucosidase Alfa, Alpha-glucosidase, Apolipoprotein B editing enzyme catalytic polypeptide like 3G, Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G, Apolipoprotein B mRNA editing enzyme catalytic subunit 3G, Brain adenylate cyclase 8, CEM-15, Ca(2+)-inhibitable adenylyl cyclase, Ca(2+)/calmodulin-activated adenylyl cyclase, D(1A) dopamine receptor, D(1B) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor, D(5) dopamine receptor, D1 beta dopamine receptor, D1A dopamine receptor, D1B dopamine receptor, D2 dopamine receptor, D2DR, D2R, D5 dopamine receptor, DADR, DBDR, DKFZp779F075, DNA dC dU editing enzyme APOBEC 3G, DNA dC->dU editing enzyme, DNA dC->dU-editing enzyme APOBEC-3G, DNA replication inhibitor, DRD 1A, DRD 1B, DRD1L2, DRD1_HUMAN, DRD2_HUMAN, DRD5_HUMAN, Dopamine D1 receptor, Dopamine D2 receptor, Dopamine D3 receptor, Dopamine D5 receptor, Dopamine receptor D1B, Dopamine receptor D2, EC 3.5.4.-, EC 4.6.1.1, FLJ12740, FLJ16822, FLJ45092, GEMI_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, Glucosidase alpha, Glucosidase alpha acid, Glucosidase alpha acid (Pompe disease glycogen storage disease type II), HBAC1, HBAC2, Hpgd, Hydroxyprostaglandin dehydrogenase 15 (NAD), KIAA0422, KIAA1060, LYAG_HUMAN, Lysosomal Alpha-Glucosidase, MDS019, MGC10601, MGC133314, NAD+ dependent 15 hydroxyprostaglandin dehydrogenase, OTTHUMP00000028911, OTTHUMP00000039393, OTTHUMP00000218960, OTTHUMP00000219016, OTTHUMP00000219018, PGDH1, PGDH_HUMAN, PHOAR1, Particulate Guanylate Cyclase E, Prostaglandin dehydrogenase 1, RP3 369A17.3, SDR36C1, Short chain dehydrogenase/reductase family 36C member 1, Type II adenylate cyclase, adenylate cyclase 3, apolipoprotein B mRNA editing enzyme cytidine deaminase, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like, bK150C2.7, dJ494G10.1, deoxycytidine deaminase, dopamine receptor D1, dopamine receptor D5, olfactive type, phorbolin-like protein, phorbolin-like protein MDS019
- Chemical Structure
Lab
Chemical Structure - (R)-(+)-SKF38393 hydrochloride, D1 partial agonist (AB120619)
2D chemical structure image of ab120619, (R)-(+)-SKF38393 hydrochloride, D1 partial agonist
Properties and storage information
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Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins fulfill essential roles in their respective systems. Geminin prevents premature DNA replication by forming part of a regulatory complex with Cdt1. Dopamine receptors like D1 D2 and D5 modulate neurotransmission and play roles in mood reward and motor function interacting with G-protein coupled receptor signaling complexes. Adenylate cyclases regulate the cAMP levels influencing numerous biological processes like hormonal signaling. APOBEC3G impacts viral replication processes particularly in retroviruses by deaminating cytidine to uridine in viral DNA. 15-PGDH controls prostaglandin levels which affect inflammatory responses.
Pathways
These proteins integrate into important cellular and neurological circuits. Geminin's role in inhibiting Cdt1 is potent in the cell cycle and replication licensing pathway ensuring DNA replication fidelity. Dopamine receptors such as D1 and D2 are important components of the dopaminergic signaling pathways which include interactions with proteins like CAMP-dependent protein kinase (PKA) that translate dopamine binding into cellular responses. Adenylate cyclases such as AC3 and AC8 play roles in the cAMP signaling pathway impacting cellular metabolism. APOBEC3G is linked to antiviral pathways often interacting with proteins involved in restricting viral replication.
Publications (1)
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Scientific reports 11:1843 PubMed33469071
2021
Applications
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Species
Unspecified reactive species
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