MW 267.35 Da, Purity >99%. Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
Images
Key facts
- CAS number
- 161735-79-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 267.35 Da
- Molecular formula
- C13H17NO3S
- PubChem identifier
- 3052775
- Nature
- Synthetic
Alternative names
Amine oxidase (flavin containing), Amine oxidase (flavin containing) A, Amine oxidase (flavin containing) B, MAO, MAO-A, MAO-B, Monoamine oxidase, Monoamine oxidase A, Monoamine oxidase B, Monoamine oxidase type A, Monoamine oxidase type B
Recommended products
MW 267.35 Da, Purity >99%. Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
Key facts
- CAS number
- 161735-79-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 267.35 Da
- Molecular formula
- C13H17NO3S
- PubChem identifier
- 3052775
- Nature
- Synthetic
- Biochemical name
- Rasagiline mesylate
- Biological description
Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
- Canonical SMILES
- CS(=O)(=O)O.C#CCNC1CCC2=CC=CC=C12
- Isomeric SMILES
- CS(=O)(=O)O.C#CCN[C@@H]1CCC2=CC=CC=C12
- InChI
- InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
- InChIKey
- JDBJJCWRXSVHOQ-UTONKHPSSA-N
- IUPAC name
- methanesulfonic acid;(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Monoamine oxidase A and B (MAO-A and MAO-B) are enzymes that reside primarily in the outer membrane of mitochondria. They catalyze the oxidative deamination of monoamines which include neurotransmitters such as serotonin dopamine and norepinephrine. MAO-A has a molecular mass of approximately 59 kDa while MAO-B is around 58 kDa. These enzymes are expressed in various tissues with high levels in the brain liver and gastrointestinal tract. They are also known as MAO-A and MAO-B and they play a critical role in regulation of synaptic neurotransmitter levels.
- Biological function summary
These enzymes are important for modulating the activity and concentration of neurotransmitters within the central nervous system and peripheral tissues. MAO enzymes ensure proper neurotransmitter homeostasis which affects mood arousal and stress response. They do not form part of larger enzyme complexes but regulate neurotransmitter concentrations individually. The functional balance between MAO-A and MAO-B activity is important for maintaining normal physiological and psychological states.
- Pathways
These enzymes are integral to the catecholamine and serotonin degradation pathways. MAO-A preferentially degrades serotonin and norepinephrine whereas MAO-B primarily acts on phenylethylamine and benzylamine although both can oxidize dopamine. Related proteins within these pathways include catechol-O-methyltransferase (COMT) and aldehyde dehydrogenases which continue the breakdown processes of monoamines into their final excretory products.
- Associated diseases and disorders
Dysfunction of MAO-A and MAO-B has links to psychiatric and neurodegenerative disorders. MAO-A abnormalities are associated with depression and mood disorders while altered MAO-B activity correlates with Parkinson’s disease. The imbalance involving these enzymes can affect neurotransmitter levels leading to disease progression. Proteins such as alpha-synuclein associated with Parkinson's disease have connections to MAO-B through their functional roles in dopaminergic neuron degeneration.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Chemical Structure - Rasagiline mesylate, MAO-B inhibitor (ab120236)
2D chemical structure image of ab120236, Rasagiline mesylate, MAO-B inhibitor
Functional Studies - Rasagiline mesylate, MAO-B inhibitor (ab120236)
ab131457 staining Bcl2 in SK-N-SH cells treated with rasagiline mesylate (ab120236), by ICC/IF. Increase in Bcl2 expression correlates with increased concentration of rasagiline mesylate, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120236 (rasagiline mesylate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab131457 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com