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AB216314

Regorafenib, multikinase inhibitor

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MW 482.8 Da. Potent multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent for animal in vivo studies. Not suitable for human consumption.
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Chemical Structure - Regorafenib, multikinase inhibitor (AB216314)
  • Chemical Structure

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Chemical Structure - Regorafenib, multikinase inhibitor (AB216314)

2D chemical structure image of ab216314, Regorafenib, multikinase inhibitor

Key facts

CAS number

755037-03-7

Form

Solid

form

Molecular weight

482.8 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>1</sub><sub>5</sub>ClF<sub>4</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

11167602

Nature

Synthetic

Solubility

Soluble in DMSO (>50mg/ml)

Slightly soluble in ethanol (1mg/ml)

Insoluble in water

Biochemical name

Regorafenib

Biological description

Potent multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent for animal in vivo studies. Not suitable for human consumption.

Canonical smiles

CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

InChi

InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChiKey

FNHKPVJBJVTLMP-UHFFFAOYSA-N

IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

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Complementary Products

Primary Antibodies

AB137110

Anti-P4HB antibody [EPR9499]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-P4HB antibody [EPR9499] (AB137110)

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Primary Antibodies

AB133497

Anti-Flotillin 1 antibody [EPR6041]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Flotillin 1 antibody [EPR6041] (AB133497)

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Primary Antibodies

AB312318

Anti-Apolipoprotein B antibody [EPR27473-49]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Apolipoprotein B antibody [EPR27473-49] (AB312318)

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Primary Antibodies

AB112995

Anti-Calnexin antibody [6F12BE10]

BOND RX™ Validated|KO Validated

Western blot - Anti-Calnexin antibody [6F12BE10] (AB112995)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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Product protocols

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Product promise

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