RepSox, TGF-beta type 1 receptor inhibitor

Key facts

CAS number

446859-33-2

Purity

>98%

Form

Solid

form

Molecular weight

287.32 Da

Molecular formula

C₁₇H₁₃N₅

PubChem

449054

Nature

Synthetic

Biochemical name

RepSox

Biological description

Selective TGF-β type 1 receptor and ALK5 autophosphorylation inhibitor (IC₅₀ = 4 nM for ALK5). Selective for ALK5 over a range of other kinases, including p38 MAPK, JNK1 and GSK3. Replaces Sox2 for reprogramming iPSCs. Active in vitro and in vivo. Cell-permeable.

Canonical smiles

CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

InChi

InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChiKey

LBPKYPYHDKKRFS-UHFFFAOYSA-N

IUPAC Name

2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine