RepSox, TGF-beta type 1 receptor inhibitor

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(6 Publications)

MW 287.32 Da, Purity >98%. Selective TGF-β type 1 receptor and ALK5 autophosphorylation inhibitor (IC₅₀ = 4 nM for ALK5). Selective for ALK5 over a range of other kinases, including p38 MAPK, JNK1 and GSK3. Replaces Sox2 for reprogramming iPSCs. Active in vitro and in vivo. Cell-permeable. .

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AAT 5, ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1_HUMAN, ACVRLK 4, ALK-5, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Activin A receptor type II like kinase, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin receptor-like kinase 5, Bcr/c abl oncogene protein, Cellular Yes 1 protein, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, HsT441, JTK7, LDS1A, LDS2A, MSSE, NR3B1, Nuclear receptor subfamily 3 group B member 1, P150, Proto oncogene tyrosine protein kinase ABL1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Abl, Proto-oncogene c-Yes, SKR 4, Serine/threonine-protein kinase receptor R4, Steroid hormone receptor ERR1, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TbetaR-I, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Yes, Viral oncogene yes 1 homolog 1, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, activin A receptor type II-like protein kinase of 53kD, bcr/abl, c ABL, c Yes, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene 1 receptor tyrosine kinase, estrogen receptor related receptor alpha, hERR1, p61-Yes, v abl, v abl Abelson murine leukemia viral oncogene homolog 1, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1