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AB120726

Resveratrol, Antioxidant polyphenol

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(8 Publications)

MW 228.24 Da, Purity >99%. Polyphenol found in grape skins and red wine. Displays a multitude of biological activities including antioxidant, antiplatelet, antitumor, anti-inflammatory and cardioprotective effects. Additionally, shows antiamyloidogenic and fibril-destabilizing activities.
2 Images
Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (AB120726)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (AB120726)

ab85555 staining PKM2 in HeLa cells treated with resveratrol (ab120726), by ICC/IF. Decrease in PKM2 expression correlates with increased concentration of resveratrol as described in literature.
The cells were incubated at 37°C for 48h in media containing different concentrations of ab120726 (resveratrol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab85555 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Resveratrol, Antioxidant polyphenol (AB120726)
  • Chemical Structure

Lab

Chemical Structure - Resveratrol, Antioxidant polyphenol (AB120726)

2D chemical structure image of ab120726, Resveratrol, Antioxidant polyphenol

Key facts

CAS number

501-36-0

Purity

>99%

Form

Solid

form

Molecular weight

228.24 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>2</sub>O<sub>3</sub>

PubChem

445154

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Resveratrol

Biological description

Polyphenol found in grape skins and red wine. Displays a multitude of biological activities including antioxidant, antiplatelet, antitumor, anti-inflammatory and cardioprotective effects. Additionally, shows antiamyloidogenic and fibril-destabilizing activities.

Canonical smiles

C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O

Isomeric smiles

C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

InChi

InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

InChiKey

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

IUPAC Name

5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of equine science 34:67-72 PubMed37781569

2023

Effects of resveratrol and its analogues on the cell cycle of equine mesenchymal stem/stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Norihisa Tamura,Neda Heidari,Richard G A Faragher,Roger K W Smith,Jayesh Dudhia

International journal for parasitology. Drugs and drug resistance 20:54-64 PubMed36099853

2022

In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection.

Applications

Unspecified application

Species

Unspecified reactive species

Matías E Rodriguez,Valeria Tekiel,Vanina A Campo

Scientific reports 12:1537 PubMed35087161

2022

Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Henok Kessete Afewerky,Hao Li,Tongmei Zhang,Xinyan Li,Yacoubou Abdoul Razak Mahaman,Limin Duan,Pengwei Qin,Jiequn Zheng,Lei Pei,Youming Lu

Journal of animal science and biotechnology 10:67 PubMed31413827

2019

Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Nevoral,Lukas Landsmann,Miriam Stiavnicka,Petr Hosek,Jiri Moravec,Sarka Prokesova,Hedvika Rimnacova,Eliska Koutna,Pavel Klein,Kristyna Hoskova,Tereza Zalmanova,Tereza Fenclova,Jaroslav Petr,Milena Kralickova

Cell death & disease 9:767 PubMed29991742

2018

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Qiang Yao,Xin Zhang,Yongqi Zhen,Xu-Ying He,Shuangmei Zhao,Xi-Feng Li,Bo Yang,Feng Gao,Fu-You Guo,Leilei Fu,Xian-Zhi Liu,Chuan-Zhi Duan

Neuroreport 29:368-379 PubMed29360689

2018

Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Guo,Jiangtao Xie,Junjie Zhao,Tingqin Huang,Xiaoye Guo,Jinning Song

Journal of animal science and biotechnology 8:83 PubMed29118980

2017

SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development.

Applications

Unspecified application

Species

Unspecified reactive species

Katerina Adamkova,Young-Joo Yi,Jaroslav Petr,Tereza Zalmanova,Kristyna Hoskova,Pavla Jelinkova,Jiri Moravec,Milena Kralickova,Miriam Sutovsky,Peter Sutovsky,Jan Nevoral

International journal for parasitology. Drugs and drug resistance 7:23-33 PubMed28038431

2016

Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.

Applications

Unspecified application

Species

Unspecified reactive species

Vanina A Campo
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