JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB145869

Reversan, MRP1 and P-glycoprotein inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 441.53 g/mol, Purity >99%. Selective MRP1 and P-glycoprotein inhibitor. Chemosensitizing agent. Increases the sensitivity of MRP1-overexpressing tumor cells to doxorubicin (ab120629), vincristine (ab120226) and etoposide (ab120227). Shows chemosensitizing, antitumor effects in vivo. .
1 Images
Chemical Structure - Reversan, MRP1 and P-glycoprotein inhibitor (AB145869)
  • Chemical Structure

Lab

Chemical Structure - Reversan, MRP1 and P-glycoprotein inhibitor (AB145869)

2D chemical structure image of ab145869, Reversan, MRP1 and P-glycoprotein inhibitor

Key facts

CAS number

313397-13-6

Purity

>99%

Form

Solid

form

Molecular weight

441.53 g/mol

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>7</sub>N<sub>5</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in ethanol to 5 mM

Soluble i in DMSO to 25 mM

Biological description

Selective MRP1 and P-glycoprotein inhibitor. Chemosensitizing agent. Increases the sensitivity of MRP1-overexpressing tumor cells to doxorubicin (ab120629), vincristine (ab120226) and etoposide (ab120227). Shows chemosensitizing, antitumor effects in vivo.

Canonical smiles

C1COCCN1CCCNC(=O)C2=C3N=C(C=C(N3N=C2)C4=CC=CC=C4)C5=CC=CC=C5

InChi

InChI=1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)

InChiKey

JTRXWCLQFAZHGP-UHFFFAOYSA-N

IUPAC Name

N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

style
left-column

Complementary Products

Biochemicals

AB144589

Mdivi-1, Drp1 inhibitor

Chemical Structure - Mdivi-1, Drp1 inhibitor (AB144589)

  • 0
  • 0
Biochemicals

AB141398

Cisplatin, antineoplastic agent

Chemical Structure - Cisplatin, antineoplastic agent (AB141398)

  • 3
  • 1
Biochemicals

AB120629

Doxorubicin hydrochloride, Topoisomerase II inhibitor

Chemical Structure - Doxorubicin hydrochloride, Topoisomerase II inhibitor (AB120629)

  • 0
  • 0
Biochemicals

AB145725

Probenecid, ABC-transporter inhibitor

Chemical Structure - Probenecid, ABC-transporter inhibitor (AB145725)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 286:678-687 PubMed30653821

2019

NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaopeng Wen,Kazumi Iwata,Keiko Ikuta,Xueqing Zhang,Kai Zhu,Masakazu Ibi,Misaki Matsumoto,Nozomi Asaoka,Junjie Liu,Masato Katsuyama,Chihiro Yabe-Nishimura
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com