MW 334.3 Da, Purity >99%. Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
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- Pain research & management 2020:15283622020DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun Liu et. al.PubMed 32148597
- Nature medicine 24:1599-16102018Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancesca Zanconato et. al.PubMed 30224758
- Frontiers in molecular neuroscience 11:3322018Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJessica Saunders et. al.PubMed 30258352
- Scientific reports 7:101522017Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLucia Bialesova et. al.PubMed 28860604
Key facts
- CAS number
- 48208-26-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 334.3 Da
- Molecular formula
- C19H14N2O4
- PubChem identifier
- 702558
- Nature
- Synthetic
Alternative names
ADCADN, AIM, CXXC finger protein 9, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA MTase, DNA MTase HsaI, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA methyltransferase M.HsaI., DNMT, DNMT1_HUMAN, Dnmt1o, FLJ16293, HSN1E, M.HsaI, MCMT, MGC104992, Met1, MommeD2, mMmul
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MW 334.3 Da, Purity >99%. Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
Key facts
- CAS number
- 48208-26-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 334.3 Da
- Molecular formula
- C19H14N2O4
- PubChem identifier
- 702558
- Nature
- Synthetic
- Biochemical name
- N-Phthalyl-L-tryptophan
- Biological description
Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
- Canonical SMILES
- C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O
- Isomeric SMILES
- C1=CC=C2C(=C1)C(=O)N(C2=O)[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O
- InChI
- InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1
- InChIKey
- HPTXLHAHLXOAKV-INIZCTEOSA-N
- IUPAC name
- (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) (ab141013)
2D chemical structure image of ab141013, RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)
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