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AB141013

RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)

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(4 Publications)

MW 334.3 Da, Purity >99%. Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.

View Alternative Names

ADCADN, AIM, CXXC finger protein 9, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA MTase, DNA MTase HsaI, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA methyltransferase M.HsaI., DNMT, DNMT1_HUMAN, Dnmt1o, FLJ16293, HSN1E, M.HsaI, MCMT, MGC104992, Met1, MommeD2, mMmul

1 Images
Chemical Structure - RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) (AB141013)
  • Chemical Structure

Lab

Chemical Structure - RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) (AB141013)

2D chemical structure image of ab141013, RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)

Key facts

CAS number

48208-26-0

Purity

>99%

Form

Solid

form

Molecular weight

334.3 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>4</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

702558

Nature

Synthetic

Biochemical name

N-Phthalyl-L-tryptophan

Biological description

Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.

Canonical smiles

C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O

Isomeric smiles

C1=CC=C2C(=C1)C(=O)N(C2=O)[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O

InChi

InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1

InChiKey

HPTXLHAHLXOAKV-INIZCTEOSA-N

IUPAC Name

(2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Pain research & management 2020:1528362 PubMed32148597

2020

DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Liu,Hao Wu,Rui Gao,Guang Han

Nature medicine 24:1599-1610 PubMed30224758

2018

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

Applications

Unspecified application

Species

Unspecified reactive species

Francesca Zanconato,Giusy Battilana,Mattia Forcato,Letizia Filippi,Luca Azzolin,Andrea Manfrin,Erika Quaranta,Daniele Di Biagio,Gianluca Sigismondo,Vincenza Guzzardo,Pascale Lejeune,Bernard Haendler,Jeroen Krijgsveld,Matteo Fassan,Silvio Bicciato,Michelangelo Cordenonsi,Stefano Piccolo

Frontiers in molecular neuroscience 11:332 PubMed30258352

2018

Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Saunders,Zoe Hore,Clive Gentry,Stephen McMahon,Franziska Denk

Scientific reports 7:10152 PubMed28860604

2017

Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Lucia Bialesova,Agné Kulyté,Paul Petrus,Indranil Sinha,Jurga Laurencikiene,Chunyan Zhao,Karin Dahlman Wright,Peter Arner,Ingrid Dahlman
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