MW 346.34 Da, Purity >95%. RGD (Arg-Gly-Asp), sequence involved in cell adhesion. Achieve your results faster with highly validated, pure and trusted compounds.
99896-85-2
> 95%
Solid
346.34 Da
C12H22N6O6
104802
Synthetic
BDPLT16, BDPLT2, CD 51, CD 61, CD41, CD41B, CD61 antigen, DKFZp686A08142, FLJ26658, GP 2B, GP 3A, GP IIIa, GP IIb, GPalpha IIb, GT, GTA, HPA 1, HPA 4, HPA3, ITA2B_HUMAN, ITAV_HUMAN, ITB3_HUMAN, ITB5_HUMAN, ITG B3, ITGA2B, ITGAB, ITGAV, Integrin alpha 2b, Integrin alpha IIb, Integrin alpha five, Integrin alpha-5, Integrin alpha-IIb light chain, Integrin alpha-V light chain, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61), Integrin beta chain beta 3, Integrin beta-3, Integrin beta-5, Integrin subunit beta 5, Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), Itgb5, MSK 8, NAIT, PPP1R93, PTP, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein IIIa, Platelet glycoprotein IIIa precursor, Platelet glycoprotein IIb of IIb/IIIa complex, Platelet membrane glycoprotein IIIa, Platelet membrane glycoprotein IIb, Testis secretory sperm-binding protein Li 217p, VNRA, VTNR, Vitronectin receptor subunit alpha, antigen CD41, antigen identified by monoclonal antibody L230, form 2, integrin alpha V beta 3, integrin alpha-V, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), platelet fibrinogen receptor, platelet fibrinogen receptor, alpha subunit, platelet specific antigen BAK
MW 346.34 Da, Purity >95%. RGD (Arg-Gly-Asp), sequence involved in cell adhesion. Achieve your results faster with highly validated, pure and trusted compounds.
99896-85-2
> 95%
Solid
346.34 Da
C12H22N6O6
104802
Synthetic
Soluble in water to 10 mM.
Arginyl-glycyl-aspartic acid
C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N
C(C[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O)N)CN=C(N)N
InChI=1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
IYMAXBFPHPZYIK-BQBZGAKWSA-N
(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid
Ambient - Can Ship with Ice
-20°C
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha V also known as CD41 and Integrins beta 3 and beta 5 are transmembrane receptors with different masses according to their subunits. These integrins interact with the extracellular matrix facilitating cell adhesion and signaling. One key feature of these integrins is their binding to the arg-gly-asp (RGD) sequence found in matrix proteins important for cellular attachment. Integrin alpha V has a wide expression in various tissues including endothelial cells osteoclasts and epithelial tissues indicating its role in diverse cellular contexts.
Integrins alpha V CD41 beta 3 and beta 5 contribute to cellular processes by forming heterodimers. These complexes participate actively in cell signaling migration and angiogenesis. The arg-gly-asp (RGD) motif serves as an important link between integrins and their matrix ligands impacting interactions with fibronectin and vitronectin. By mediating cellular activities through these complex formations integrins contribute to vital biological functions such as wound healing and tissue remodeling.
These integrins play significant roles in both the PI3K/AKT and MAPK pathways. These pathways are critical for transmitting signals from the extracellular environment to intracellular effectors influencing cell proliferation survival and mobility. The integrins interact functionally with proteins like focal adhesion kinase (FAK) and Src family kinases which further propagate signaling events. Their involvement in these pathways links them to various cellular responses and physiological processes.
Integrins alpha V and beta 3 are associated with cancer progression and cardiovascular diseases. Their expression and signaling roles contribute to tumor invasion angiogenesis and atherosclerosis development. In cancer these integrins interact with matrix metalloproteinases which degrade extracellular matrix components and facilitate metastasis. Understanding their interactions and pathways offers insight into potential therapeutic targets for treating these conditions.
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2D chemical structure image of ab142698, RGD (Arg-Gly-Asp), sequence involved in cell adhesion
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