RGDS peptide, Fibronectin inhibitor
Be the first to review this product! Submit a review
|
(1 Publication)
MW 433.42 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.
View Alternative Names
AA407068, Antigen identified by monoclonal antibody J143, BDPLT16, BDPLT2, BR, CD 49b, CD 61, CD41, CD41B, CD49 antigen-like family member B, CD49 antigen-like family member C, CD49 antigen-like family member E, CD49b antigen, CD49c, CD49c antigen, CD49e, CD61 antigen, CD_antigen=CD29, Collagen Receptor, DX5, FLJ34631, FLJ34704, FNRA, FNRB, FRP-2, Fibronectin receptor subunit alpha, Fibronectin receptor subunit beta, Fibronectin receptor, alpha subunit, GAP B3, GP 2B, GP 3A, GP IIIa, GP IIa, GP IIb, GP Ia, GP Ia deficiency, included, GPalpha IIb, GT, GTA, Galactoprotein B3, Glycoprotein IIa, Glycoprotein Ia deficiency included, HPA 1, HPA 4, HPA 5 included, HPA3, Human platelet alloantigen system 5, ITA2B_HUMAN, ITA2_HUMAN, ITA3_HUMAN, ITA5_HUMAN, ITB1_HUMAN, ITB3_HUMAN, ITG B3, ITGA 3, ITGA2, ITGA2B, ITGAB, ITGB1, Integrin alpha 2b, Integrin alpha 3, Integrin alpha 5 (fibronectin receptor alpha), Integrin alpha II, Integrin alpha IIb, Integrin alpha-2, Integrin alpha-3 light chain, Integrin alpha-5, Integrin alpha-5 light chain, Integrin alpha-F, Integrin alpha-IIb light chain, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61), Integrin beta chain beta 3, Integrin beta-1, Integrin beta-3, Integrin subunit beta 1, Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor), Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), Integrin, alpha 5 (fibronectin receptor, alpha polypeptide), Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), Itga5, MDF2, MSK12, MSK18, NAIT, OTTHUMP00000019420, PPP1R93, PTP, Platelet alloantigen Br(a), included, Platelet antigen Br, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein GPIa, Platelet glycoprotein IIIa, Platelet glycoprotein IIIa precursor, Platelet glycoprotein IIb of IIb/IIIa complex, Platelet glycoprotein Ia, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein IIIa, Platelet membrane glycoprotein IIb, Platelet membrane glycoprotein Ia, Platelet receptor for collagen, deficiency of, included, VCA 2, VL3A, VLA 2, VLA 2 alpha chain, VLA 3 alpha chain, VLA-2 subunit alpha, VLA-3 subunit alpha, VLA-4 subunit beta, VLA-5, VLA-BETA, VLA2 receptor alpha 2 subunit, VLA3a, VLA5A, VLAA2, VLAB, Very late activation protein 2 receptor alpha 2 subunit, Very late activation protein 3 receptor alpha 3 subunit, Very late activation protein 5, alpha subunit, Very late activation protein, beta polypeptide, antigen CD41, beta1 integrin, form 2, integrin VLA-4 beta subunit, platelet fibrinogen receptor, platelet fibrinogen receptor, alpha subunit, platelet specific antigen BAK, very late activation protein
- Chemical Structure
Lab
Chemical Structure - RGDS peptide, Fibronectin inhibitor (AB230365)
2D chemical structure image of ab230365, RGDS peptide, Fibronectin inhibitor
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Integrins participate in key cellular functions like migration proliferation and survival. They are parts of larger protein complexes at the cell surface acting together with other proteins to transmit signals inside the cell. Integrins specifically engage with extracellular matrix components like fibronectin and collagen influencing cellular responses to the external environment. The GRGDS peptide known to mimic fibronectin binding sites serves as an inhibitor to some integrin-mediated interactions by competing with natural ligands.
Pathways
Integrins are critical components in integrin-mediated signaling pathways and the cellular response to fibronectin. These pathways involve interactions with signaling proteins such as focal adhesion kinase (FAK) and Src family kinases which facilitate signal transduction from the extracellular matrix into the cell interior. Such pathways modulate cytoskeleton organization and gene expression. The integrin fibronectin binding is particularly significant in pathways that regulate cell shape and motility and is connected to Rac and Rho GTPases by downstream signaling cascades.
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
Oxidative medicine and cellular longevity 2022:1671438 PubMed35720180
2022
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com