MW 1123.9 Da, Purity >93%. Cell-permeable fluorescent Ca2+ indicator. Binds to Ca2+ (Kd = 570 nM) and fluoresces yellow/orange upon Ca2+ binding. Cell-impermeable form, Rhod-2 K+ salt (ab142781) also available. Ex550/Em578.
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- Biomolecules & therapeutics 32:349-3602024Morroniside Protects C2C12 Myoblasts from Oxidative Damage Caused by ROS-Mediated Mitochondrial Damage and Induction of Endoplasmic Reticulum Stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHyun Hwangbo,Cheol Park,EunJin Bang,Hyuk Soon Kim,Sung-Jin Bae,Eunjeong Kim,Youngmi Jung,Sun-Hee Leem,Young Rok Seo,Su Hyun Hong,Gi-Young Kim,Jin Won Hyun,Yung Hyun ChoiPubMed 38602043
- Scientific reports 13:206852023Biophysical properties of Na1.5 channels from atrial-like and ventricular-like cardiomyocytes derived from human induced pluripotent stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCharles-Albert Chapotte-Baldacci,Marion Pierre,Mohammed Djemai,Valérie Pouliot,Mohamed ChahinePubMed 38001331
- Nature communications 14:62262023Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChaojie Yu,Mingyue Shi,Shaoshuai He,Mengmeng Yao,Hong Sun,Zhiwei Yue,Yuwei Qiu,Baijun Liu,Lei Liang,Zhongming Zhao,Fanglian Yao,Hong Zhang,Junjie LiPubMed 37803005
- Frontiers in physiology 14:12583182023Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarion Pierre,Mohammed Djemai,Charles-Albert Chapotte-Baldacci,Valérie Pouliot,Jack Puymirat,Mohamed Boutjdir,Mohamed ChahinePubMed 37791351
- Cell reports 42:1128832023COPI-regulated mitochondria-ER contact site formation maintains axonal integrity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel C Maddison,Bilal Malik,Leonardo Amadio,Dana M Bis-Brewer,Stephan Züchner,Owen M Peters,Gaynor A SmithPubMed 37498742
- Cellular oncology (Dordrecht) 46:1031-10482023RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHui Yao,Siyu Zhang,Haijing Xie,Yue Fan,Mengyu Miao,Rui Zhu,Ling Yuan,Miao Gu,Yiwen You,Bo YouPubMed 36952101
- iScience 26:1063282023Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Yang,Mengjia Sun,Renzheng Chen,Xiaowei Ye,Boji Wu,Zhen Liu,Jihang Zhang,Xubin Gao,Ran Cheng,Chunyan He,Jingyu He,Xuhong Wang,Lan HuangPubMed 36968068
- British journal of pharmacology 180:1862-18772023Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMan Jiang,Yi-Xin Zhang,Wen-Jie Bu,Ping Li,Jia-Hui Chen,Ming Cao,Yan-Chao Dong,Zhi-Jie Sun,De-Li DongPubMed 36740831
- The Journal of biological chemistry 299:1028372022Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTakeshi Ikizawa,Kazutaka Ikeda,Makoto Arita,Shojiro Kitajima,Tomoyoshi Soga,Hidenori Ichijo,Isao NaguroPubMed 36581206
- ACS nano 16:16234-162482022An Intrapericardial Injectable Hydrogel Patch for Mechanical-Electrical Coupling with Infarcted Myocardium.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChaojie Yu,Zhiwei Yue,Mingyue Shi,Lijie Jiang,Shuang Chen,Mengmeng Yao,Qingyu Yu,Xiaojun Wu,Hong Zhang,Fanglian Yao,Changyong Wang,Hong Sun,Junjie LiPubMed 36190461
Key facts
- CAS number
145037-81-6
- Purity
> 93%
- Form
Solid
- Molecular weight
1123.9 Da
- Molecular formula
C52H59BrN4O19
- PubChem identifier
25229581
- Nature
Synthetic
- Excitation/Emission
Ex: 552nm, Em: 581nm
Target data
Recommended products
MW 1123.9 Da, Purity >93%. Cell-permeable fluorescent Ca2+ indicator. Binds to Ca2+ (Kd = 570 nM) and fluoresces yellow/orange upon Ca2+ binding. Cell-impermeable form, Rhod-2 K+ salt (ab142781) also available. Ex550/Em578.
Key facts
- CAS number
145037-81-6
- Purity
> 93%
- Form
Solid
- Molecular weight
1123.9 Da
- Molecular formula
C52H59BrN4O19
- PubChem identifier
25229581
- Nature
Synthetic
- Solubility
Soluble in DMSO to 1 mg/ml.
- Biochemical name
Rhod-2 AM
- Biological description
Cell-permeable fluorescent Ca2+ indicator. Binds to Ca2+ (Kd = 570 nM) and fluoresces yellow/orange upon Ca2+ binding. Cell-impermeable form, Rhod-2 K+ salt (ab142781) also available. Ex550/Em578.
- Canonical SMILES
CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC(=C2)C3=C4C=CC(=[N+](C)C)C=C4OC5=C3C=CC(=C5)N(C)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C.[Br-]
- InChI
InChI=1S/C52H59N4O19.BrH/c1-32-10-16-42(55(24-48(61)71-28-67-33(2)57)25-49(62)72-29-68-34(3)58)46(20-32)65-18-19-66-47-21-37(11-17-43(47)56(26-50(63)73-30-69-35(4)59)27-51(64)74-31-70-36(5)60)52-40-14-12-38(53(6)7)22-44(40)75-45-23-39(54(8)9)13-15-41(45)52;/h10-17,20-23H,18-19,24-31H2,1-9H3;1H/q+1;/p-1
- InChIKey
RWXWZOWDWYQKBK-UHFFFAOYSA-M
- IUPAC name
[9-[4-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-3-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium;bromide
- Excitation/Emission
Ex: 552nm, Em: 581nm
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
Notes
The Ester Rhod-2 once hydrolyzed by cellular endogenous esterases will bind Ca2+ and localizes to mitochondria,
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1 product image
Chemical Structure - Rhod-2 AM, fluorescent Ca2+ indicator (ab142780)
2D chemical structure image of ab142780, Rhod-2 AM, fluorescent Ca2+ indicator
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