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AB120795

Rhodadyn™ C10, cell-permeable dynamin I inhibitor

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MW 350.49 g/mol, Purity >98%. Highly potent cell-permeable dynamin I GTPase activity inhibitor (IC50 values are 7.1 and 30.3 μM at dynamin I and dynamin II, respectively). Blocks clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture (IC50 = 7.0 μM).
Rhodadyn™ B10 negative control also available (ab120796).

Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012).
1 Images
Chemical Structure - Rhodadyn™ C10, cell-permeable dynamin I inhibitor (AB120795)
  • Chemical Structure

Lab

Chemical Structure - Rhodadyn™ C10, cell-permeable dynamin I inhibitor (AB120795)

2D chemical structure image of ab120795, Rhodadyntrade C10, cell-permeable dynamin I inhibitor

Key facts

CAS number

1367579-04-1

Purity

>98%

Form

Solid

form

Molecular weight

350.49 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O<sub>2</sub>S<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Highly potent cell-permeable dynamin I GTPase activity inhibitor (IC50 values are 7.1 and 30.3 μM at dynamin I and dynamin II, respectively). Blocks clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture (IC50 = 7.0 μM).
Rhodadyn™ B10 negative control also available (ab120796).

Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012).

IUPAC Name

(5Z)-5-[4-[3-(Dimethylamino)propoxy]benzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one

Product details

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovations Ltd. Rhodadyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

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