MW 434.5 Da, Purity >=98%. Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).
B cell CLL/lymphoma 1, BCL-1, BCL-1 oncogene, C-2K, CCND3_HUMAN, CCNT, CCNT1_HUMAN, CDC2L4, CDK4 protein, CDK4_HUMAN, CDK9 associated C type protein, CDK9_HUMAN, CMM 3, Cdc2-related kinase, Cell division cycle 2-like protein kinase 4, Cell division kinase 4, Cell division protein kinase 4, Cell division protein kinase 6, Cell division protein kinase 9, Crk3, Cyc T1, Cyclin C related protein, Cyclin T1b, Cyclin-T, Cyclin-T1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Cyclin-dependent kinase 9, CyclinD3, D3 type cyclin, G1 S specific cyclin D1, G1 S specific cyclin D3, G1/S-specific cyclin-D3, HIVE1, Human immunodeficiency virus 1 expression, Human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1, MGC14458, Melanoma cutaneous malignant 3, PITALRE, PRAD1, PRAD1 oncogene, PSK-J3, Serine threonine protein kinase PLSTIRE, Serine/threonine-protein kinase PITALRE, Subunit of positive elongation transcription factor b, TAK, Tat associated kinase complex catalytic subunit, cyclin D1 1, p34 cdk4, pTEFb subunit
MW 434.5 Da, Purity >=98%. Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).
Soluble in DMSO to ~10 mM.
Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).
This product is manufactured by BioVision, an Abcam company and was previously called 9481 Ribociclib (LEE011). 9481-5 is the same size as the 5 mg size of ab285415.
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