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AB285415

Ribociclib (LEE011)

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MW 434.5 Da, Purity >98%. Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).

Key facts

CAS number

1211441-98-3

Purity

>98%

Form

Solid

form

Molecular weight

434.5 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>3</sub><sub>0</sub>N<sub>8</sub>O

PubChem

44631912

Nature

Synthetic

Solubility

Soluble in DMSO to ~10 mM

Biochemical name

Ribociclib

Biological description

Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).

Canonical smiles

CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

InChi

InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)

InChiKey

RHXHGRAEPCAFML-UHFFFAOYSA-N

IUPAC Name

7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Complementary Products

Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Biochemicals

AB218118

PD0332991, Cdk4/Cdk6 inhibitor

  • 0
  • 0
Reagents, Controls & Accessories

AB288006

RIPA Buffer

  • 0
  • 0
Reagents, Controls & Accessories

AB156034

10X RIPA Buffer

SDS-PAGE - 10X RIPA Buffer (AB156034)

  • 5
  • 2
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 9481 Ribociclib (LEE011). 9481-5 is the same size as the 5 mg size of ab285415.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Product promise

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