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AB120393

Risperidone, 5-HT2A / D2 antagonist

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(3 Publications)

MW 410.5 Da, Purity >99%. Atypical antipsychotic agent. Potent 5-HT2A antagonist (Ki = 0.4 nM). Also displays high affinity at D2 receptors (Ki = 3.13 nM).
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Chemical Structure - Risperidone, 5-HT2A / D2 antagonist (AB120393)
  • Chemical Structure

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Chemical Structure - Risperidone, 5-HT2A / D2 antagonist (AB120393)

2D chemical structure image of ab120393, Risperidone, 5-HT2A / D2 antagonist

Key facts

CAS number

106266-06-2

Purity

>99%

Form

Solid

form

Molecular weight

410.5 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>7</sub>FN<sub>4</sub>O<sub>2</sub>

PubChem

5073

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 10 mM

Biochemical name

Risperidone

Biological description

Atypical antipsychotic agent. Potent 5-HT2A antagonist (Ki = 0.4 nM). Also displays high affinity at D2 receptors (Ki = 3.13 nM).

Canonical smiles

CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

InChi

InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

InChiKey

RAPZEAPATHNIPO-UHFFFAOYSA-N

IUPAC Name

3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

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Complementary Products

Primary Antibodies

AB216959

Anti-5HT2A Receptor antibody

Western blot - Anti-5HT2A Receptor antibody (AB216959)

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Primary Antibodies

AB133570

Anti-5-HT2C Receptor antibody [EPR6487]

20ul selling size|RabMAb|Recombinant|Trial Size

Western blot - Anti-5-HT2C Receptor antibody [EPR6487] (AB133570)

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Biochemicals

AB120555

alpha-Methyl 5-hydroxytryptamine maleate, 5-HT2A/2C receptor agonist

Chemical Structure - alpha-Methyl 5-hydroxytryptamine maleate, 5-HT2A/2C receptor agonist (AB120555)

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Biochemicals

AB120132

Ketanserin tartrate, 5-HT2 antagonist

Chemical Structure - Ketanserin tartrate, 5-HT2 antagonist (AB120132)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Alzheimer's & dementia (New York, N. Y.) 6:e12078 PubMed32864416

2020

Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects.

Applications

Unspecified application

Species

Unspecified reactive species

Yasaman Malekizadeh,Gareth Williams,Mark Kelson,David Whitfield,Jonathan Mill,David A Collier,Clive Ballard,Aaron R Jeffries,Byron Creese

Psychopharmacology 234:3259-3269 PubMed28812124

2017

Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.

Applications

Unspecified application

Species

Unspecified reactive species

William W Blessing,Esther M Blessing,Mazher Mohammed,Youichirou Ootsuka

Psychopharmacology 231:269-81 PubMed23954911

2013

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.

Applications

Unspecified application

Species

Rat

Katarzyna Fijał,Piotr Popik,Agnieszka Nikiforuk
View all publications
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