Skip to main content

MW 452.4 Da, Purity >97%. Potent, cell-permeable LSD-1 inhibitor (IC50 = 70 nM). Selective for LSD-1 versus MAO-A (IC50 = 0.51 μM) and MAO-B (IC50 = 2.79 μM). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Be the first to review this product! Submit a review

Key facts

CAS number
1781835-13-9
Purity
> 97%
Form
Solid
Molecular weight
452.4 Da
Molecular formula
C23H31Cl2N3O2
PubChem identifier
90488995
Nature
Synthetic

Target data

Recommended products

MW 452.4 Da, Purity >97%. Potent, cell-permeable LSD-1 inhibitor (IC50 = 70 nM). Selective for LSD-1 versus MAO-A (IC50 = 0.51 μM) and MAO-B (IC50 = 2.79 μM). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Key facts

Purity
> 97%
PubChem identifier
90488995
Solubility

DMSO: 8 mg/mL.

Water: 8 mg/mL.

Biochemical name
RN-1 Dihydrochloride
Biological description

Potent, cell-permeable LSD-1 inhibitor (IC50 = 70 nM). Selective for LSD-1 versus MAO-A (IC50 = 0.51 μM) and MAO-B (IC50 = 2.79 μM). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Canonical SMILES
CN1CCN(CC1)C(=O)CNC2CC2C3=CC=C(C=C3)OCC4=CC=CC=C4.Cl.Cl
Isomeric SMILES
CN1CCN(CC1)C(=O)CN[C@@H]2C[C@H]2C3=CC=C(C=C3)OCC4=CC=CC=C4.Cl.Cl
InChI
InChI=1S/C23H29N3O2.2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18;;/h2-10,21-22,24H,11-17H2,1H3;2*1H/t21-,22+;;/m0../s1
InChIKey
WMHAFZOOUBPQRX-VSIGASKDSA-N
IUPAC name
1-(4-methylpiperazin-1-yl)-2-[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone;dihydrochloride

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2080 RN 1 dihydrochloride. B2080-5 is the same size as the 25 mg size of ab254240.

Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from air and moisture.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

0 product images

    Downloads

    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

    Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

    For licensing inquiries, please contact partnerships@abcam.com