JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB254240

RN-1 dihydrochloride

Be the first to review this product! Submit a review

|

(0 Publication)

MW 452.4 Da, Purity >97%. Potent, cell-permeable LSD-1 inhibitor (IC50 = 70 nM). Selective for LSD-1 versus MAO-A (IC50 = 0.51 μM) and MAO-B (IC50 = 2.79 μM). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Key facts

CAS number

1781835-13-9

Purity

>97%

Form

Solid

form

Molecular weight

452.4 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>3</sub><sub>1</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

90488995

Nature

Synthetic

Solubility

DMSO: 8 mg/mL

Water: 8 mg/mL

Biochemical name

RN-1 Dihydrochloride

Biological description

Potent, cell-permeable LSD-1 inhibitor (IC50 = 70 nM). Selective for LSD-1 versus MAO-A (IC50 = 0.51 μM) and MAO-B (IC50 = 2.79 μM). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Canonical smiles

CN1CCN(CC1)C(=O)CNC2CC2C3=CC=C(C=C3)OCC4=CC=CC=C4.Cl.Cl

Isomeric smiles

CN1CCN(CC1)C(=O)CN[C@@H]2C[C@H]2C3=CC=C(C=C3)OCC4=CC=CC=C4.Cl.Cl

InChi

InChI=1S/C23H29N3O2.2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18;;/h2-10,21-22,24H,11-17H2,1H3;2*1H/t21-,22+;;/m0../s1

InChiKey

WMHAFZOOUBPQRX-VSIGASKDSA-N

IUPAC Name

1-(4-methylpiperazin-1-yl)-2-[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone;dihydrochloride

style
left-column

Complementary Products

Assay Kits

AB207003

BCA protein assay kit reducing agent compatible (microplate)

Functional Studies - BCA protein assay kit reducing agent compatible (microplate) (AB207003)

  • 0
  • 0
Assay Kits

AB207002

BCA protein assay kit for low concentrations

Functional Studies - BCA protein assay kit for low concentrations (AB207002)

  • 0
  • 0
Assay Kits

AB287853

BCA Protein Assay Kit II

Functional Studies - BCA Protein Assay Kit II (AB287853)

  • 0
  • 0
Assay Kits

AB102536

BCA Protein Assay Kit

Functional Studies - BCA Protein Assay Kit (AB102536)

  • 0
  • 0
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2080 RN 1 dihydrochloride. B2080-5 is the same size as the 25 mg size of ab254240.

Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from air and moisture.

style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com