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AB254522

RN-1734, TRPV4 antagonist

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(1 Publication)

MW 353.3 Da. Novel, selective TRPV4 antagonist. (IC50 values are 2.3, 3.2 and 5.9μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.
1 Images
Chemical Structure - RN-1734, TRPV4 antagonist (AB254522)
  • Chemical Structure

Supplier Data

Chemical Structure - RN-1734, TRPV4 antagonist (AB254522)

2D chemical structure image of ab254522, RN-1734, TRPV4 antagonist

Key facts

CAS number

946387-07-1

Form

Solid

form

Molecular weight

353.3 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>2</sub><sub>2</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>S

PubChem

3601086

Nature

Synthetic

Solubility

Soluble in DMSO up to 50mM

Biochemical name

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

Biological description

Novel, selective TRPV4 antagonist. (IC50 values are 2.3, 3.2 and 5.9μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Canonical smiles

CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl

InChi

InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3

InChiKey

IHYZMEAZAIFMTN-UHFFFAOYSA-N

IUPAC Name

2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
+4°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biological & pharmaceutical bulletin 44:1759-1766 PubMed34719652

2021

Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shotaro Michinaga,Kazuya Onishi,Kahori Shimizu,Hiroyuki Mizuguchi,Shigeru Hishinuma
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