Ro 08-2750

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MW 270.24 Da, Purity 98%. An antagonist of nerve growth factor (NGF) with binding ratio of 1:1, IC₅₀ = 1 μM. Selectively inhibits binding to p75NTR over TRKA147 at low concentrations. However, it can impair NGF binding to TrkA at higher concentrations (more than 5 mM).

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5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, AD 022, Beta-NGF, Beta-nerve growth factor, EAP 2, EAP II, ETS1-associated protein 2, ETS1-associated protein II, HSAN5, High affinity nerve growth factor receptor, High affinity nerve growth factor receptor precursor, MGC111021, MGC161426, MGC161428, MGC9099, MTC, NGFB, NGF_HUMAN, NID67, NTRK1_HUMAN, Nerve growth factor, Nerve growth factor (beta polypeptide), Nerve growth factor beta, Nerve growth factor beta polypeptide, Nerve growth factor beta subunit, Neurotrophic tyrosine kinase receptor type 1, Oncogene TRK, RP1-30M3.3, Slow nerve growth, TRAF and TNF receptor-associated protein, TRK, TRK1, TRK1-transforming tyrosine kinase protein, TTRAP, TYDP2_HUMAN, Trk-A, Tropomyosin-related kinase A, Tyr-DNA phosphodiesterase 2, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tyrosyl-DNA phosphodiesterase 2, dJ30M3.3, gp140trk, p14-TrkA, p140-TrkA