Ro 106-9920, NF-kappaB inhibitor

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MW 245.26 Da, Purity >95%. NF-κB inhibitor. Anti-inflammatory agent. Selectively inhibits LPS- and TNF-α-induced IκBα ubiquitination (IC₅₀ = 3 μM). Inhibits TNF-α, IL-1β and IL-6 production. Shows anti-inflammatory effects in vivo. Orally active.

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1 25 dihydroxyvitamin D3 receptor, 15-PGDH, 15-hydroxyprostaglandin dehydrogenase [NAD+], 25-dihydroxyvitamin D3 receptor, AHDC, AI838772, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, AW493413, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, Deubiquitinating enzyme 1, FLJ11090, FLJ92943, Hpgd, Hydroxyprostaglandin dehydrogenase 15 (NAD), IMD42, LFS1, Liver mitochondrial ALDH, MGC104252, MGC112732, MGC129539, MGC1806, MGC2318, Member 1, Mitochondrial aldehyde dehydrogenase 2, Mutant tumor protein 53, NAD+ dependent 15 hydroxyprostaglandin dehydrogenase, NR1F3, NR1I1, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 1, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, OTTHUMP00000218960, OTTHUMP00000219016, OTTHUMP00000219018, P53_HUMAN, PGDH1, PGDH_HUMAN, PHOAR1, PPP1R163, PUMB 1, Phosphoprotein p53, Prostaglandin dehydrogenase 1, Protein phosphatase 1, regulatory subunit 163, RALDH 1, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SCAN1, SDR36C1, Short chain dehydrogenase/reductase family 36C member 1, TOR, TRP53, TYDP, TYDP1_HUMAN, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, UBP, UBP1_HUMAN, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin specific peptidase 1, Ubiquitin specific protease 1, Ubiquitin thioesterase 1, Ubiquitin thiolesterase 1, Ubiquitin-specific-processing protease 1, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, hUBP, p53 tumor suppressor, tumor antigen p55