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AB141491

Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor

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(6 Publications)

MW 351.4 Da, Purity >99%. Selective cyclin-dependent kinase (Cdk1) inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A, respectively). Enhances downstream p53 signaling. Induces G2/M-phase cell cycle arrest and apoptosis.
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Chemical Structure - Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor (AB141491)
  • Chemical Structure

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Chemical Structure - Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor (AB141491)

2D chemical structure image of ab141491, Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor

Key facts

CAS number

872573-93-8

Purity

>99%

Form

Solid

form

Molecular weight

351.4 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>3</sub>N<sub>3</sub>OS<sub>2</sub>

PubChem

11631681

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 11631681

Biological description

Selective cyclin-dependent kinase (Cdk1) inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A, respectively). Enhances downstream p53 signaling. Induces G2/M-phase cell cycle arrest and apoptosis.

Canonical smiles

C1=CC2=C(C=CC(=C2)C=C3C(=O)N=C(S3)NCC4=CC=CS4)N=C1

Isomeric smiles

C1=CC2=C(C=CC(=C2)/C=C\3/C(=O)N=C(S3)NCC4=CC=CS4)N=C1

InChi

InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-

InChiKey

XOLMRFUGOINFDQ-YBEGLDIGSA-N

IUPAC Name

(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e38729 PubMed39512465

2024

Establishment of prognosis model of hepatocellular carcinoma based on prognosis related gene analysis and study on gene regulation mechanism of model.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Dai,Bo Yang,Abdusemer Reyimu,Weiqiang Li,Wubi Zhou,Xiang Wang,Weijie Dai,Wan Wang,Jianghong Yan,Suxia Hu

Evidence-based complementary and alternative medicine : eCAM 2022:4026688 PubMed36588592

2022

Caudatin Inhibits the Proliferation, Invasion, and Glycolysis of Osteosarcoma Cells via the Wnt/- Catenin Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhang,Zhizhong Sheng,Chi Su,Yuli Xia,Xiangfan Chen,Xiaobo Huang,Honglin Li,Changsheng Ma,Ligang Wang

Nature communications 12:90 PubMed33397943

2021

Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng-Rung Huang,Cheng-Ju Kuo,Chih-Wen Huang,Yu-Ting Chen,Bang-Yu Liu,Chung-Ta Lee,Po-Lin Chen,Wen-Tsan Chang,Yun-Wen Chen,Tzer-Min Lee,Hui-Chen Hsieh,Chang-Shi Chen

PLoS computational biology 16:e1008300 PubMed33035221

2020

Nuclear plasticity increases susceptibility to damage during confined migration.

Applications

Unspecified application

Species

Unspecified reactive species

Abhishek Mukherjee,Amlan Barai,Ramesh K Singh,Wenyi Yan,Shamik Sen

Bio-protocol 10:e3577 PubMed33659547

2020

Fractionation of Ovarian Follicles and Oocyte Maturation and Ovulation Assay of Type A.

Applications

Unspecified application

Species

Unspecified reactive species

Shin Matsubara,Akira Shiraishi,Tomohiro Osugi,Tsuyoshi Kawada,Honoo Satake

eLife 8: PubMed31573508

2019

The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates.

Applications

Unspecified application

Species

Unspecified reactive species

Shin Matsubara,Akira Shiraishi,Tomohiro Osugi,Tsuyoshi Kawada,Honoo Satake
View all publications
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