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AB120979

Ro 67-4853, Positive allosteric modulator of mGlu1

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MW 325.36 g/mol, Purity >99%. Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).

View Alternative Names

GLUR, Smp_128940

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Chemical Structure - Ro 67-4853, Positive allosteric modulator of mGlu1 (AB120979)
  • Chemical Structure

Lab

Chemical Structure - Ro 67-4853, Positive allosteric modulator of mGlu1 (AB120979)

2D chemical structure image of ab120979, Ro 67-4853, Positive allosteric modulator of mGlu1

Key facts

CAS number

302841-89-0

Purity

>99%

Form

Solid

form

Molecular weight

325.36 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).

IUPAC Name

N-(9H-Xanthen-9-ylcarbonyl)carbamic acid butyl ester

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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