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MW 325.36 g/mol, Purity >99%.

Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).

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Images

Chemical Structure - Ro 67-4853, Positive allosteric modulator of mGlu1 (AB120979), expandable thumbnail

Key facts

CAS number
302841-89-0
Purity
> 99%
Form
Solid
Molecular weight
325.36 g/mol
Nature
Synthetic

Target data

Alternative names

GLUR, Smp_128940

Recommended products

MW 325.36 g/mol, Purity >99%.

Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).

Key facts

Purity
> 99%
Solubility

Soluble in DMSO to 100 mM.

Biological description

Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).

IUPAC name
N-(9H-Xanthen-9-ylcarbonyl)carbamic acid butyl ester

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - Ro 67-4853, Positive allosteric modulator of mGlu1 (ab120979), expandable thumbnail

    Chemical Structure - Ro 67-4853, Positive allosteric modulator of mGlu1 (ab120979)

    2D chemical structure image of ab120979, Ro 67-4853, Positive allosteric modulator of mGlu1

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Product protocols

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