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AB141847

Roscovitine, CDK inhibitor

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(1 Publication)

MW 354.4 Da, Purity >99%. Cell-permeable, selective inhibitor of cyclin-dependent kinases (CDKs), displaying higher potency and selectivity compared to olomoucine (ab120938). p34cdc2 inhibitor (IC50 = 0.2 μM). Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic.

Key facts

CAS number

186692-46-6

Purity

>99%

Form

Solid

form

Molecular weight

354.4 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>6</sub>N<sub>6</sub>O

PubChem

160355

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 25 mM

Biochemical name

Seliciclib

Biological description

Cell-permeable, selective inhibitor of cyclin-dependent kinases (CDKs), displaying higher potency and selectivity compared to olomoucine (ab120938). p34cdc2 inhibitor (IC50 = 0.2 μM). Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic.

Canonical smiles

CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3

Isomeric smiles

CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3

InChi

InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

InChiKey

BTIHMVBBUGXLCJ-OAHLLOKOSA-N

IUPAC Name

(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol

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Complementary Products

Primary Antibodies

AB40890

Anti-Cyclin E2 antibody [EP454Y]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin E2 antibody [EP454Y] (AB40890)

  • 5
  • 1
Biochemicals

AB146240

DEPC, ryanodine/Ca2+ channel binding inhibitor

Chemical Structure - DEPC, ryanodine/Ca2+ channel binding inhibitor (AB146240)

  • 0
  • 0
Assay Kits

AB195215

Human IgG ELISA Kit

SimpleStep

Sandwich ELISA - Human IgG ELISA Kit (AB195215)

  • 4
  • 6
Biochemicals

AB142072

IPTG, Allosteric lac repressor protein inhibitor

Chemical Structure - IPTG, Allosteric lac repressor protein inhibitor (AB142072)

  • 0
  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 29:4144-4158.e7 PubMed31851939

2019

Discrimination of Dormant and Active Hematopoietic Stem Cells by G Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.

Applications

Unspecified application

Species

Unspecified reactive species

Tsuyoshi Fukushima,Yosuke Tanaka,Fiona K Hamey,Chih-Hsiang Chang,Toshihiko Oki,Shuhei Asada,Yasutaka Hayashi,Takeshi Fujino,Taishi Yonezawa,Reina Takeda,Kimihito Cojin Kawabata,Tomofusa Fukuyama,Terumasa Umemoto,Keiyo Takubo,Hitoshi Takizawa,Susumu Goyama,Yasushi Ishihama,Hiroaki Honda,Berthold Göttgens,Toshio Kitamura
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