MW 473.5 Da, Purity >98%. Potent, selective PPARγ agonist (EC50 = 43 nM). Maleate salt. Improves adipocyte function, restores insulin sensitivity, and inhibits atherosclerosis in vivo. Orally active.
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- Cells 12:2023PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing He,Ruotong Zhang,Lexiang Yu,Tarik Zahr,Xueming Li,Tae-Wan Kim,Li QiangPubMed 37408258
- Life metabolism 1:258-2692022Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole Aaron,Tarik Zahr,Ying He,Lexiang Yu,Brent Mayfield,Utpal B Pajvani,Li QiangPubMed 37213714
- eLife 10:2021Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole Aaron,Michael J Kraakman,Qiuzhong Zhou,Qiongming Liu,Samantha Costa,Jing Yang,Longhua Liu,Lexiang Yu,Liheng Wang,Ying He,Lihong Fan,Hiroyuki Hirakawa,Lei Ding,James Lo,Weidong Wang,Baohong Zhao,Edward Guo,Lei Sun,Cliff J Rosen,Li QiangPubMed 34155972
- Diabetes 69:1793-18032020PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLonghua Liu,Lihong Fan,Michelle Chan,Michael J Kraakman,Jing Yang,Yong Fan,Nicole Aaron,Qianfen Wan,Maria Alicia Carrillo-Sepulveda,Alan R Tall,Ira Tabas,Domenico Accili,Li QiangPubMed 32409492
- The Journal of biological chemistry 294:6751-67612019Identification of a natural beige adipose depot in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichelle Chan,Yen Ching Lim,Jing Yang,Maria Namwanje,Longhua Liu,Li QiangPubMed 30824545
- The Journal of clinical investigation 128:2600-26122018PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael J Kraakman et. al.PubMed 29589839
Key facts
- CAS number
- 155141-29-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 473.5 Da
- Molecular formula
- C22H23N3O7S
- PubChem identifier
- 5281055
- Nature
- Synthetic
Alternative names
2700049B16Rik, 3110031N04Rik, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, Drosophila slowpoke like, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, NR1C3, Nuclear receptor subfamily 1 group C member 3, PPAR-gamma, PPARG2, PPARG_HUMAN, Peroxisome proliferator activated receptor gamma 2, Peroxisome proliferator-activated receptor gamma, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, SAKCA, SLO, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, bA350O14.10, cytokeratin-associated protein, hSlo, hslo beta, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4
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MW 473.5 Da, Purity >98%. Potent, selective PPARγ agonist (EC50 = 43 nM). Maleate salt. Improves adipocyte function, restores insulin sensitivity, and inhibits atherosclerosis in vivo. Orally active.
Key facts
- CAS number
- 155141-29-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 473.5 Da
- Molecular formula
- C22H23N3O7S
- PubChem identifier
- 5281055
- Nature
- Synthetic
- Solubility
Soluble in DMSO.
Soluble in ethanol.
- Biochemical name
- Rosiglitazone maleate
- Biological description
Potent, selective PPARγ agonist (EC50 = 43 nM). Maleate salt. Improves adipocyte function, restores insulin sensitivity, and inhibits atherosclerosis in vivo. Orally active.
- Canonical SMILES
- CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
- Isomeric SMILES
- CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=C\C(=O)O)\C(=O)O
- InChI
- InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
- InChIKey
- SUFUKZSWUHZXAV-BTJKTKAUSA-N
- IUPAC name
- (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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Chemical Structure - Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt. (ab142461)
2D chemical structure image of ab142461, Rosiglitazone maleate (Avandia), PPARgamma agonist. Maleate salt.
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