MW 357.4 Da, Purity >99%. Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.
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- Life (Basel, Switzerland) 12:2022Dysregulation of the Amniotic PPARγ Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPARγ in Human Fetal Membranes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAudrey Antoine,Coraline De Sousa Do Outeiro,Coline Charnay,Corinne Belville,Fanny Henrioux,Denis Gallot,Loïc Blanchon,Régine Minet-Quinard,Vincent SapinPubMed 35455039
- PPAR research 2021:60862652021Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR- to Inhibit the NF-B/NLRP3 Inflammatory Axis in Spinal Cord Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Fu,Baoxia Zhao,Chaobo Ni,Huadong Ni,Longsheng Xu,Qiuli He,Miao Xu,Chengfei Xu,Ge Luo,Jianjun Zhu,Jiachun Tao,Ming YaoPubMed 34484316
- Oncology reports 45:317-3282021Beige adipocytes contribute to breast cancer progression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMariana Gantov,Priscila Pagnotta,Cecilia Lotufo,Gustavo Marcelo Rindone,Maria Fernanda Riera,Juan Carlos Calvo,Judith ToneattoPubMed 33416183
- Bone 120:219-2312018Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuko Katoh-Fukui,Takashi Baba,Tetsuya Sato,Hiroyuki Otake,Yuko Nagakui-Noguchi,Miyuki Shindo,Mikita Suyama,Yasuyuki Ohkawa,Hideki Tsumura,Ken-Ichirou Morohashi,Maki FukamiPubMed 30389610
- BMC musculoskeletal disorders 18:4232017Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXia Chen et. al.PubMed 29073887
- Molecular medicine reports 16:8200-82082017Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator‑activated receptor‑γ.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Xing Wu et. al.PubMed 28983607
- Nature communications 7:134572016Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephen L Pinkosky et. al.PubMed 27892461
- Biochimica et biophysica acta 1842:1513-242014Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnastasia Asimakopoulou et. al.PubMed 25086218
Key facts
- CAS number
- 122320-73-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 357.4 Da
- Molecular formula
- C18H19N3O3S
- PubChem identifier
- 77999
- Nature
- Synthetic
Target data
Recommended products
MW 357.4 Da, Purity >99%. Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.
Key facts
- CAS number
- 122320-73-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 357.4 Da
- Molecular formula
- C18H19N3O3S
- PubChem identifier
- 77999
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM (with warming).
- Biochemical name
- Rosiglitazone
- Biological description
Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.
- Canonical SMILES
- CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
- InChI
- InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
- InChIKey
- YASAKCUCGLMORW-UHFFFAOYSA-N
- IUPAC name
- 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Rosiglitazone, PPARgamma agonist (ab120762)
2D chemical structure image of ab120762, Rosiglitazone, PPARgamma agonist
Immunocytochemistry/ Immunofluorescence - Rosiglitazone, PPARgamma agonist (ab120762)
Anti-Glucocorticoid Receptor alpha antibody ab3580 staining glucocorticoid receptor in serum starved HeLa cells treated with rosiglitazone (120762), by ICC/IF. Changes in localization of glucocorticoid receptor (translocation from cytoplasm to nucleous) correlates with increased concentration of rosiglitazone, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120762 (rosiglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-Glucocorticoid Receptor alpha antibody ab3580 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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