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AB120762

Rosiglitazone, PPARgamma agonist

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(9 Publications)

MW 357.4 Da, Purity >99%. Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.
2 Images
Immunocytochemistry/ Immunofluorescence - Rosiglitazone, PPARgamma agonist (AB120762)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Rosiglitazone, PPARgamma agonist (AB120762)

ab3580 staining glucocorticoid receptor in serum starved HeLa cells treated with rosiglitazone (120762), by ICC/IF. Changes in localization of glucocorticoid receptor (translocation from cytoplasm to nucleous) correlates with increased concentration of rosiglitazone, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120762 (rosiglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab3580 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Rosiglitazone, PPARgamma agonist (AB120762)
  • Chemical Structure

Lab

Chemical Structure - Rosiglitazone, PPARgamma agonist (AB120762)

2D chemical structure image of ab120762, Rosiglitazone, PPARgamma agonist

Key facts

CAS number

122320-73-4

Purity

>99%

Form

Solid

form

Molecular weight

357.4 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>9</sub>N<sub>3</sub>O<sub>3</sub>S

PubChem

77999

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM (with warming)

Biochemical name

Rosiglitazone

Biological description

Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.

Canonical smiles

CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3

InChi

InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)

InChiKey

YASAKCUCGLMORW-UHFFFAOYSA-N

IUPAC Name

5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Open medicine (Warsaw, Poland) 19:20240900 PubMed38463531

2024

Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Guojin Liang,Jie Fang,Pingping Zhang,Shuxia Ding,Yudan Zhao,Yueying Feng

Life (Basel, Switzerland) 12: PubMed35455039

2022

Dysregulation of the Amniotic PPARγ Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPARγ in Human Fetal Membranes.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey Antoine,Coraline De Sousa Do Outeiro,Coline Charnay,Corinne Belville,Fanny Henrioux,Denis Gallot,Loïc Blanchon,Régine Minet-Quinard,Vincent Sapin

PPAR research 2021:6086265 PubMed34484316

2021

Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR- to Inhibit the NF-B/NLRP3 Inflammatory Axis in Spinal Cord Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Fu,Baoxia Zhao,Chaobo Ni,Huadong Ni,Longsheng Xu,Qiuli He,Miao Xu,Chengfei Xu,Ge Luo,Jianjun Zhu,Jiachun Tao,Ming Yao

Oncology reports 45:317-328 PubMed33416183

2021

Beige adipocytes contribute to breast cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Mariana Gantov,Priscila Pagnotta,Cecilia Lotufo,Gustavo Marcelo Rindone,Maria Fernanda Riera,Juan Carlos Calvo,Judith Toneatto

Bone 120:219-231 PubMed30389610

2018

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.

Applications

Unspecified application

Species

Unspecified reactive species

Yuko Katoh-Fukui,Takashi Baba,Tetsuya Sato,Hiroyuki Otake,Yuko Nagakui-Noguchi,Miyuki Shindo,Mikita Suyama,Yasuyuki Ohkawa,Hideki Tsumura,Ken-Ichirou Morohashi,Maki Fukami

BMC musculoskeletal disorders 18:423 PubMed29073887

2017

Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Chen,Junsong Chen,Dongliang Xu,Shuangxia Zhao,Huaidong Song,Yongde Peng

Molecular medicine reports 16:8200-8208 PubMed28983607

2017

Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator‑activated receptor‑γ.

Applications

Unspecified application

Species

Unspecified reactive species

Ying-Xing Wu,Yue Sun,Ya-Ping Ye,Peng Zhang,Jia-Chao Guo,Jun-Ming Huang,Xing-Zhi Jing,Wei Xiang,Shi-Ying Yu,Feng-Jing Guo

Nature communications 7:13457 PubMed27892461

2016

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen L Pinkosky,Roger S Newton,Emily A Day,Rebecca J Ford,Sarka Lhotak,Richard C Austin,Carolyn M Birch,Brennan K Smith,Sergey Filippov,Pieter H E Groot,Gregory R Steinberg,Narendra D Lalwani

Biochimica et biophysica acta 1842:1513-24 PubMed25086218

2014

Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver.

Applications

Unspecified application

Species

Unspecified reactive species

Anastasia Asimakopoulou,Erawan Borkham-Kamphorst,Marc Henning,Eray Yagmur,Nikolaus Gassler,Christian Liedtke,Thorsten Berger,Tak W Mak,Ralf Weiskirchen
View all publications
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