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AB120812

RS 102895 hydrochloride, CCR2 receptor antagonist

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(5 Publications)

MW 426.9 Da, Purity >99%. Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
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Chemical Structure - RS 102895 hydrochloride, CCR2 receptor antagonist (AB120812)
  • Chemical Structure

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Chemical Structure - RS 102895 hydrochloride, CCR2 receptor antagonist (AB120812)

2D chemical structure image of ab120812, RS 102895 hydrochloride, CCR2 receptor antagonist

Key facts

CAS number

300815-41-2

Purity

>99%

Form

Solid

form

Molecular weight

426.9 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>2</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

16759153

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

RS 102895 hydrochloride

Biological description

Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.

Canonical smiles

C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl

InChi

InChI=1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H

InChiKey

KRRISOFSWVKYBF-UHFFFAOYSA-N

IUPAC Name

1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 30:21 PubMed38317079

2024

Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Akira Okekawa,Tsutomu Wada,Yasuhiro Onogi,Yuki Takeda,Yuichiro Miyazawa,Masakiyo Sasahara,Hiroshi Tsuneki,Toshiyasu Sasaoka

Cancer gene therapy 30:22-37 PubMed35999359

2022

CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Bin Wang,You-Xin Gao,Yin-Hua Ye,Tong-Xing Lin,Ping Li,Jian-Xian Lin,Qi-Yue Chen,Long-Long Cao,Mi Lin,Ru-Hong Tu,Ju-Li Lin,Ze-Ning Huang,Hua-Long Zheng,Jian-Wei Xie,Chao-Hui Zheng,Chang-Ming Huang

BMC developmental biology 20:20 PubMed33023470

2020

Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangcheng Zhan,Jingwei Zhang,Saiyang Li,Xiaolu Zhang,Linchao Li,Tiantian Song,Qunlong Liu,Jun Lu,Yunfei Xu,Ren-Shan Ge

American journal of translational research 11:442-452 PubMed30788000

2019

High CCL7 expression is associated with migration, invasion and bone metastasis of non-small cell lung cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Han,Ting Wang,Yuanming Chen,Zhitao Han,Lihan Guo,Zhipeng Wu,Wangjun Yan,Haifeng Wei,Tielong Liu,Jian Zhao,Wang Zhou,Xinghai Yang,Jianru Xiao

Oncotarget 8:9739-9751 PubMed28039457

2017

Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Aerken Maolake,Kouji Izumi,Kazuyoshi Shigehara,Ariunbold Natsagdorj,Hiroaki Iwamoto,Suguru Kadomoto,Yuta Takezawa,Kazuaki Machioka,Kazutaka Narimoto,Mikio Namiki,Wen-Jye Lin,Guzailinuer Wufuer,Atsushi Mizokami
View all publications
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