MW 426.9 Da, Purity >99%. Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
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- Molecular medicine (Cambridge, Mass.) 30:212024Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAkira Okekawa,Tsutomu Wada,Yasuhiro Onogi,Yuki Takeda,Yuichiro Miyazawa,Masakiyo Sasahara,Hiroshi Tsuneki,Toshiyasu SasaokaPubMed 38317079
- Cancer gene therapy 30:22-372022CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia-Bin Wang,You-Xin Gao,Yin-Hua Ye,Tong-Xing Lin,Ping Li,Jian-Xian Lin,Qi-Yue Chen,Long-Long Cao,Mi Lin,Ru-Hong Tu,Ju-Li Lin,Ze-Ning Huang,Hua-Long Zheng,Jian-Wei Xie,Chao-Hui Zheng,Chang-Ming HuangPubMed 35999359
- BMC developmental biology 20:202020Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiangcheng Zhan et. al.PubMed 33023470
- American journal of translational research 11:442-4522019High CCL7 expression is associated with migration, invasion and bone metastasis of non-small cell lung cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuai Han et. al.PubMed 30788000
- Oncotarget 8:9739-97512017Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAerken Maolake,Kouji Izumi,Kazuyoshi Shigehara,Ariunbold Natsagdorj,Hiroaki Iwamoto,Suguru Kadomoto,Yuta Takezawa,Kazuaki Machioka,Kazutaka Narimoto,Mikio Namiki,Wen-Jye Lin,Guzailinuer Wufuer,Atsushi MizokamiPubMed 28039457
Key facts
- CAS number
- 300815-41-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 426.9 Da
- Molecular formula
- C21H22ClF3N2O2
- PubChem identifier
- 16759153
- Nature
- Synthetic
Recommended products
MW 426.9 Da, Purity >99%. Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
Key facts
- CAS number
- 300815-41-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 426.9 Da
- Molecular formula
- C21H22ClF3N2O2
- PubChem identifier
- 16759153
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biochemical name
- RS 102895 hydrochloride
- Biological description
Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
- Canonical SMILES
- C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
- InChI
- InChI=1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
- InChIKey
- KRRISOFSWVKYBF-UHFFFAOYSA-N
- IUPAC name
- 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - RS 102895 hydrochloride, CCR2 receptor antagonist (ab120812)
2D chemical structure image of ab120812, RS 102895 hydrochloride, CCR2 receptor antagonist
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