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AB120020

(R,S)-3,5-DHPG, group I mGlu receptor agonist

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(5 Publications)

MW 183.16 Da, Purity >98%. Selective group I mGlu receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

GLUR, GPRC1A, GRM1-Alpha, GRM1_HUMAN, Glutamate receptor metabotropic 1, MGLU1, Metabotropic glutamate receptor 1, SCAR13, Smp_128940, mGluR1

2 Images
Immunocytochemistry/ Immunofluorescence - (R,S)-3,5-DHPG, group I mGlu receptor agonist (AB120020)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - (R,S)-3,5-DHPG, group I mGlu receptor agonist (AB120020)

ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-3,5-DHPG (ab120020), by ICC/IF. Increase in FMRP expression correlates with increased concentration of (R,S)-3,5-DHPG, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120020 ((R,S)-3,5-DHPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - (R,S)-3,5-DHPG, group I mGlu receptor agonist (AB120020)
  • Chemical Structure

Lab

Chemical Structure - (R,S)-3,5-DHPG, group I mGlu receptor agonist (AB120020)

2D chemical structure image of ab120020, (R,S)-3,5-DHPG, group I mGlu receptor agonist

Key facts

CAS number

146255-66-5

Purity

>98%

Form

Solid

form

Molecular weight

183.16 Da

Molecular formula

C<sub>8</sub>H<sub>9</sub>NO<sub>4</sub>

PubChem

108001

Nature

Synthetic

Biochemical name

3,5-Dihydroxyphenylglycine

Biological description

Selective group I mGlu receptor agonist

Canonical smiles

C1=C(C=C(C=C1O)O)C(C(=O)O)N

InChi

InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)

InChiKey

HOOWCUZPEFNHDT-UHFFFAOYSA-N

IUPAC Name

2-amino-2-(3,5-dihydroxyphenyl)acetic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 10:1710 PubMed30979884

2019

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Heather Bowling,Aditi Bhattacharya,Guoan Zhang,Danyal Alam,Joseph Z Lebowitz,Nathaniel Bohm-Levine,Derek Lin,Priyangvada Singha,Maggie Mamcarz,Rosemary Puckett,Lili Zhou,Sameer Aryal,Kevin Sharp,Kent Kirshenbaum,Elizabeth Berry-Kravis,Thomas A Neubert,Eric Klann

Synapse (New York, N.Y.) 73:e22097 PubMed30868621

2019

Autism-associated Shank3 mutations alter mGluR expression and mGluR-dependent but not NMDA receptor-dependent long-term depression.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Lee,Yukti Vyas,Craig C Garner,Johanna M Montgomery

The Journal of neuroscience : the official journal of the Society for Neuroscience 30:3072-81 PubMed20181604

2010

Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity.

Applications

Unspecified application

Species

Unspecified reactive species

Alan M Roloff,Garret R Anderson,Kirill A Martemyanov,Stanley A Thayer

Journal of neurochemistry 112:162-72 PubMed19840219

2009

Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Qing Li,Shao-Rui Chen,Hong Chen,You-Qing Cai,Hui-Lin Pan

Neuropharmacology 55:474-82 PubMed18625255

2008

Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings.

Applications

Unspecified application

Species

Unspecified reactive species

Veronica Musante,Elisa Neri,Marco Feligioni,Aldamaria Puliti,Marco Pedrazzi,Valerio Conti,Cesare Usai,Alberto Diaspro,Roberto Ravazzolo,Jeremy M Henley,Giuseppe Battaglia,Anna Pittaluga
View all publications
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