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AB120813

RS 504393, CCR2 chemokine receptor antagonist

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MW 417.5 Da, Purity >98%. Highly selective CCR2 chemokine receptor antagonist (IC50 = 89 nM). Shows 700-fold greater binding for CCR2 vs. CCR1. Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
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Chemical Structure - RS 504393, CCR2 chemokine receptor antagonist (AB120813)
  • Chemical Structure

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Chemical Structure - RS 504393, CCR2 chemokine receptor antagonist (AB120813)

2D chemical structure image of ab120813, RS 504393, CCR2 chemokine receptor antagonist

Key facts

CAS number

300816-15-3

Purity

>98%

Form

Solid

form

Molecular weight

417.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>7</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

9953769

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

Biological description

Highly selective CCR2 chemokine receptor antagonist (IC50 = 89 nM). Shows 700-fold greater binding for CCR2 vs. CCR1. Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Canonical smiles

CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C

InChi

InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

InChiKey

ODNICNWASXKNNQ-UHFFFAOYSA-N

IUPAC Name

6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Secondary Antibodies

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Primary Antibodies

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