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MW 186.17 Da, Purity >99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.

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Key facts

CAS number

77521-29-0

Purity

> 99%

Form

Solid

Molecular weight

186.17 Da

Molecular formula

C7H10N2O4

PubChem identifier

1221

Nature

Synthetic

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Alternative names

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MW 186.17 Da, Purity >99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.

Alternative names

Key facts

Purity

> 99%

PubChem identifier

1221

Biochemical name

alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID

Biological description

Prototypic agonist for AMPA receptors.

Canonical SMILES

CC1=C(C(=O)NO1)CC(C(=O)O)N

InChI

InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)

InChIKey

UUDAMDVQRQNNHZ-UHFFFAOYSA-N

IUPAC name

2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Supplementary info

Biological summary

The receptor facilitates communication between neurons by allowing ions to flow across the cell membrane leading to excitatory postsynaptic potentials. It often exists as a tetrameric complex with other AMPA receptor subunits such as GluA2 and GluA3 allowing for diverse combinations that affect the receptor's permeability and kinetics. These receptors are pivotal in synaptic plasticity which underlies learning and memory processes.

Mechanical summary

Glutamate Receptor 1 also known as AMPA receptor 1 or GluA1 functions mechanically as an ionotropic glutamate receptor. The protein plays a role in mediating fast synaptic transmission in the central nervous system. It binds to the neurotransmitter glutamate initiating a conformation change that opens an ion channel permeable to sodium and to a lesser extent calcium ions. GluA1 has a molecular mass of approximately 100 kDa. This receptor is expressed in various regions of the brain including the hippocampus cerebral cortex and cerebellum which are critical areas for memory and learning.

Pathway

AMPA receptor subunits GluA1 to GluA4 participate significantly in the long-term potentiation (LTP) pathway and synaptic plasticity. The LTP pathway is essential for strengthening synapses in the hippocampus. The interaction of the AMPA receptor with NMDA receptors and other proteins like stargazin and PSD-95 is important in regulating synaptic strength and plasticity. GluA receptors integrate into intricate networks modulating neuronal response to synaptic inputs.

Disease

GluA1 appears relevant to conditions like epilepsy and neurodegenerative disorders such as Alzheimer's disease. The dysregulation of AMPA receptors including GluA1 is linked to excessive excitatory signaling contributing to seizure activity and synaptic dysfunction. In Alzheimer's altered AMPA receptor trafficking and expression relate to cognitive decline. The interaction with NMDA receptors further connects these conditions via disrupted calcium signaling and excitotoxicity which are common pathological features.

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2 product images

  • Chemical Structure - (R,S)-AMPA, AMPA agonist (ab120130), expandable thumbnail

    Chemical Structure - (R,S)-AMPA, AMPA agonist (ab120130)

    2D chemical structure image of ab120130, (R,S)-AMPA, AMPA agonist

  • Functional Studies - (R,S)-AMPA, AMPA agonist (ab120130), expandable thumbnail

    Functional Studies - (R,S)-AMPA, AMPA agonist (ab120130)

    ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with (R,S)-AMPA (ab120130), by ICC/IF. Increase in MEK1 (phospho S298) expression correlates with increased concentration of(R,S)-AMPA, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120130 ((R,S)-AMPA) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

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