MW 186.17 Da, Purity >99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.
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- The international journal of neuropsychopharmacolo 18:2014Adjunctive treatment with asenapine augments the escitalopram-induced effects on monoaminergic outflow and glutamatergic neurotransmission in the medial prefrontal cortex of the rat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarl Björkholm et. al.PubMed 25522408
- The Journal of neuroscience : the official journal of the Society for Neuroscience 32:372-802012Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDe-Pei Li,Hee Sun Byan,Hui-Lin PanPubMed 22219297
- Cell death & disease 1:e542010Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA Ruiz et. al.PubMed 21364659
- Nature neuroscience 12:1069-732009Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEisuke Koya et. al.PubMed 19620976
- The European journal of neuroscience 29:1348-562009Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarco Feligioni,Atsushi Nishimune,Jeremy M HenleyPubMed 19344328
Key facts
- CAS number
- 77521-29-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 186.17 Da
- Molecular formula
- C7H10N2O4
- PubChem identifier
- 1221
- Nature
- Synthetic
Alternative names
AMPA 1, AMPA 2, AMPA 3, AMPA 4, AMPA-selective glutamate receptor 1, AMPA-selective glutamate receptor 2, AMPA-selective glutamate receptor 3, AMPA-selective glutamate receptor 4, EEA3, Excitatory amino acid receptor 1, Excitatory amino acid receptor 2, Excitatory amino acid receptor 3, Excitatory amino acid receptor 4, Excitatory amino acid receptor 5, GLR 6, GLR 7, GLR5, GLUH1, GLUK3, GLUK6, GLUR4C, GRIA1_HUMAN, GRIA2_HUMAN, GRIA3_HUMAN, GRIA4_HUMAN, GRIK, GRIK1_HUMAN, GRIK2 protein, GRIK2_HUMAN, GRIK3_HUMAN, GRIK4_HUMAN, GRIK5_HUMAN, GluA 4, GluA1, GluA2, GluA3, GluK2, GluK4, GluK5, GluR 7a, GluR-1, GluR-2, GluR-3, GluR-4, GluR-5, GluR-6, GluR-7, GluR-A, GluR-B, GluR-C, GluR-D, GluR-K1, GluR-K2, GluR-K3, GluRgamma2, Glutamate ionotropic receptor AMPA type subunit 3, Glutamate receptor, Glutamate receptor 1, Glutamate receptor 2, Glutamate receptor 3, Glutamate receptor 4, Glutamate receptor 5, Glutamate receptor 6, Glutamate receptor 7, Glutamate receptor C, Glutamate receptor KA 1precursor, Glutamate receptor KA-1, Glutamate receptor KA-2, Glutamate receptor ionotrophic AMPA 3, Glutamate receptor ionotrophic AMPA 4, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic AMPA 2, Glutamate receptor ionotropic kainate 1, Glutamate receptor ionotropic kainate 2, Glutamate receptor ionotropic kainate 3, Glutamate receptor ionotropic kainate 4, Glutamate receptor ionotropic kainate 4 precursor, Glutamate receptor subunit 3, Glutamate receptor, ionotropic kainate 5 [Precursor], Glutamate receptor, ionotropic, AMPA 3, Glutamate receptor, ionotropic, kainate 5, Glutamate receptor, ionotropic, kainate 5 (gamma 2), HBGR1, HBGR2, Human glutamate receptor GLUR5, Ionotrophic Glutamate Receptor, Ionotropic Glutamate receptor 4, KA2, MGC118086, MGC133252, MRT6, MRX94, OTTHUMP00000045951, OTTHUMP00000096569, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, OTTHUMP00000231881, bA487F5.1, dJ1171F9.1, glutamate receptor form A, glutamate receptor form B, glutamate receptor form C, glutamate receptor form D, glutamate receptor form E, iGlu5, ionotropic kainate 1, ionotropic kainate 2, ionotropic kainate 3, ionotropic kainate 4, ionotropic kainate 5
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MW 186.17 Da, Purity >99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 77521-29-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 186.17 Da
- Molecular formula
- C7H10N2O4
- PubChem identifier
- 1221
- Nature
- Synthetic
- Biochemical name
- alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
- Biological description
Prototypic agonist for AMPA receptors.
- Canonical SMILES
- CC1=C(C(=O)NO1)CC(C(=O)O)N
- InChI
- InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
- InChIKey
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N
- IUPAC name
- 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Glutamate Receptor 1 also known as AMPA receptor 1 or GluA1 functions mechanically as an ionotropic glutamate receptor. The protein plays a role in mediating fast synaptic transmission in the central nervous system. It binds to the neurotransmitter glutamate initiating a conformation change that opens an ion channel permeable to sodium and to a lesser extent calcium ions. GluA1 has a molecular mass of approximately 100 kDa. This receptor is expressed in various regions of the brain including the hippocampus cerebral cortex and cerebellum which are critical areas for memory and learning.
- Biological function summary
The receptor facilitates communication between neurons by allowing ions to flow across the cell membrane leading to excitatory postsynaptic potentials. It often exists as a tetrameric complex with other AMPA receptor subunits such as GluA2 and GluA3 allowing for diverse combinations that affect the receptor's permeability and kinetics. These receptors are pivotal in synaptic plasticity which underlies learning and memory processes.
- Pathways
AMPA receptor subunits GluA1 to GluA4 participate significantly in the long-term potentiation (LTP) pathway and synaptic plasticity. The LTP pathway is essential for strengthening synapses in the hippocampus. The interaction of the AMPA receptor with NMDA receptors and other proteins like stargazin and PSD-95 is important in regulating synaptic strength and plasticity. GluA receptors integrate into intricate networks modulating neuronal response to synaptic inputs.
- Associated diseases and disorders
GluA1 appears relevant to conditions like epilepsy and neurodegenerative disorders such as Alzheimer's disease. The dysregulation of AMPA receptors including GluA1 is linked to excessive excitatory signaling contributing to seizure activity and synaptic dysfunction. In Alzheimer's altered AMPA receptor trafficking and expression relate to cognitive decline. The interaction with NMDA receptors further connects these conditions via disrupted calcium signaling and excitotoxicity which are common pathological features.
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2 product images
Chemical Structure - (R,S)-AMPA, AMPA agonist (ab120130)
2D chemical structure image of ab120130, (R,S)-AMPA, AMPA agonist
Functional Studies - (R,S)-AMPA, AMPA agonist (ab120130)
Anti-MEK1 (phospho S298) antibody [EPR3338] ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with (R,S)-AMPA (ab120130), by ICC/IF. Increase in MEK1 (phospho S298) expression correlates with increased concentration of(R,S)-AMPA, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120130 ((R,S)-AMPA) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-MEK1 (phospho S298) antibody [EPR3338] ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody.
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