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MW 209.2 Da, Purity >99%. Group I / group II metabotropic glutamate receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033), expandable thumbnail

Publications

Key facts

CAS number

146669-29-6

Purity

> 99%

Form

Solid

Molecular weight

209.2 Da

Molecular formula

C10H11NO4

PubChem identifier

1222

Nature

Synthetic

Alternative names

Recommended products

MW 209.2 Da, Purity >99%. Group I / group II metabotropic glutamate receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity

> 99%

PubChem identifier

1222

Solubility

Soluble in 1 eq. NaOH to 100 mM.

Biochemical name

alpha-Methyl-4-carboxyphenylglycine

Biological description

Group I / group II metabotropic glutamate receptor antagonist.

Canonical SMILES

CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

InChI

InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)

InChIKey

DNCAZYRLRMTVSF-UHFFFAOYSA-N

IUPAC name

4-(1-amino-1-carboxyethyl)benzoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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Terms & Conditions.

2 product images

  • Chemical Structure - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (ab120033), expandable thumbnail

    Chemical Structure - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (ab120033)

    2D chemical structure image of ab120033, (R,S)-MCPG, Group I /II metabotropic glutamate antagonist

  • Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (ab120033), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (ab120033)

    Anti-FMRP antibody ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG (ab120033), by ICC/IF. Decrease in FMRP expression correlates with increased concentration of (R,S)-MCPG, as described in literature.
    The cells were incubated at 37°C for 2h in media containing different concentrations of ab120033 ((R,S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-FMRP antibody ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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Product protocols

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