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AB120033

(R,S)-MCPG, Group I /II metabotropic glutamate antagonist

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(7 Publications)

MW 209.2 Da, Purity >99%. Group I / group II metabotropic glutamate receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

GLUR, Smp_128940

2 Images
Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033)

ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG (ab120033), by ICC/IF. Decrease in FMRP expression correlates with increased concentration of (R,S)-MCPG, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120033 ((R,S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033)
  • Chemical Structure

Lab

Chemical Structure - (R,S)-MCPG, Group I /II metabotropic glutamate antagonist (AB120033)

2D chemical structure image of ab120033, (R,S)-MCPG, Group I /II metabotropic glutamate antagonist

Key facts

CAS number

146669-29-6

Purity

>99%

Form

Solid

form

Molecular weight

209.2 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>1</sub>NO<sub>4</sub>

PubChem

1222

Nature

Synthetic

Solubility

Soluble in 1 eq. NaOH to 100 mM

Biochemical name

alpha-Methyl-4-carboxyphenylglycine

Biological description

Group I / group II metabotropic glutamate receptor antagonist.

Canonical smiles

CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

InChi

InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)

InChiKey

DNCAZYRLRMTVSF-UHFFFAOYSA-N

IUPAC Name

4-(1-amino-1-carboxyethyl)benzoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Cerebral cortex (New York, N.Y. : 1991) 26:4160-4169 PubMed27566978

2016

Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Polina Kosillo,Yan-Feng Zhang,Sarah Threlfell,Stephanie J Cragg

Journal of neurophysiology 113:2195-209 PubMed25589590

2015

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Tristan Hedrick,Jack Waters

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:15488-503 PubMed24068817

2013

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Ingrid Chamma,Martin Heubl,Quentin Chevy,Marianne Renner,Imane Moutkine,Emmanuel Eugène,Jean Christophe Poncer,Sabine Lévi

The Journal of physiology 591:899-918 PubMed23129798

2012

Late-onset bursts evoked by mossy fibre bundle stimulation in unipolar brush cells: evidence for the involvement of H- and TRP-currents.

Applications

Unspecified application

Species

Unspecified reactive species

F Locatelli,L Bottà,F Prestori,S Masetto,E D'Angelo

Journal of cerebral blood flow and metabolism : of 32:2076-83 PubMed22929439

2012

Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Agustin Liotta,Jörg Rösner,Christine Huchzermeyer,Anna Wojtowicz,Oliver Kann,Dietmar Schmitz,Uwe Heinemann,Richard Kovács

Journal of neurophysiology 107:42-9 PubMed21994261

2011

Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Young-Hwan Jo

Cerebral cortex (New York, N.Y. : 1991) 22:1542-53 PubMed21908847

2011

A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Walid Bouthour,Félix Leroy,Charline Emmanuelli,Michèle Carnaud,Maxime Dahan,Jean Christophe Poncer,Sabine Lévi
View all publications
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