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AB120252

(R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist

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(2 Publications)

MW 231.18 Da, Purity >99%. Group I / group II metabotropic glutamate receptor antagonist. Water soluble form. Also available in Kit: mGlu antagonists (ab120322).

Also available in simple stock solutions (ab146689) - add 1 ml of water to get an exact, ready-to-use concentration.
2 Images
Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (AB120252)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (AB120252)

ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG sodium salt (ab120252), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (R,S)-MCPG sodium salt, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120252 ((R,S)-MCPG sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (AB120252)
  • Chemical Structure

Lab

Chemical Structure - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (AB120252)

2D chemical structure image of ab120252, (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist

Key facts

CAS number

1303994-09-3

Purity

>99%

Form

Solid

form

Molecular weight

231.18 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>0</sub>NNaO<sub>4</sub>

PubChem

133698095

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

(R,S)-MCPG sodium salt

Biological description

Group I / group II metabotropic glutamate receptor antagonist. Water soluble form. Also available in Kit: mGlu antagonists (ab120322).

Also available in simple stock solutions (ab146689) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

CC(C1=CC=C(C=C1)C(=O)O)(C(=O)[O-])N.[Na+]

InChi

InChI=1S/C10H11NO4.Na/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13;/h2-5H,11H2,1H3,(H,12,13)(H,14,15);/q;+1/p-1

InChiKey

YPWQKZZVAZJJRO-UHFFFAOYSA-M

IUPAC Name

sodium;2-amino-2-(4-carboxyphenyl)propanoate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:15692 PubMed29146949

2017

A Microfluidic Platform for the Characterisation of CNS Active Compounds.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher MacKerron,Graham Robertson,Michele Zagnoni,Trevor J Bushell

Environmental health perspectives 33:191-202 PubMed120252

1979

Health effects of the gas-aerosol complex. Report to Special Committee on Health and Ecological Effects of Increased Coal Utilization.

Applications

Unspecified application

Species

Unspecified reactive species

B D Goldstein
View all publications
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