MW 275.34 Da, Purity >99%. Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively).
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- STAR protocols 3:1015442022Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYukiko Ishikura,Hiroshi Ohta,Masahiro Nagano,Mitinori SaitouPubMed 35842863
- The EMBO journal 41:e1094572022Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJacqueline Severino,Moritz Bauer,Tom Mattimoe,Niccolò Arecco,Luca Cozzuto,Patricia Lorden,Norio Hamada,Yoshiaki Nosaka,So I Nagaoka,Pauline Audergon,Antonio Tarruell,Holger Heyn,Katsuhiko Hayashi,Mitinori Saitou,Bernhard PayerPubMed 35603814
- Scientific reports 12:35892022The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEllis Nelissen,Nina Possemis,Nick P Van Goethem,Melissa Schepers,Danielle A J Mulder-Jongen,Lisa Dietz,Wiebke Janssen,Michael Gerisch,Jörg Hüser,Peter Sandner,Tim Vanmierlo,Jos PrickaertsPubMed 35246566
- Biomedicines 9:2021Soluble Guanylate Cyclase Stimulator Vericiguat Enhances Long-Term Memory in Rats without Altering Cerebral Blood Volume.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEllis Nelissen,Elentina K Argyrousi,Nick P Van Goethem,Fuqiang Zhao,Catherine D G Hines,Gayathri Swaminath,Michael Gerisch,Joerg Hueser,Peter Sandner,Jos PrickaertsPubMed 34440254
- Cells 10:2021Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFaraz Ahmad,Yu Jing,Albert Lladó,Ping LiuPubMed 34065927
- The EMBO journal 39:e1049292020Long-term expansion with germline potential of human primordial germ cell-like cells in vitro.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYusuke Murase,Yukihiro Yabuta,Hiroshi Ohta,Chika Yamashiro,Tomonori Nakamura,Takuya Yamamoto,Mitinori SaitouPubMed 32954504
- Science (New York, N.Y.) 327:547-522010Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaya Shelly,Byung Kook Lim,Laura Cancedda,Sarah C Heilshorn,Hongfeng Gao,Mu-ming PooPubMed 20110498
Key facts
- CAS number
- 61413-54-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 275.34 Da
- Molecular formula
- C16H21NO3
- PubChem identifier
- 5092
- Nature
- Synthetic
Target data
Alternative names
5''-cyclic phosphodiesterase 4A, DPDE2, PDE4, PDE46, PDE4A11, PDE4A_HUMAN, Phosphodiesterase 4A, Phosphodiesterase 4A, cAMP-specific (dunce, Phosphodiesterase E2 dunce homolog, Drosophila, cAMP specific phosphodiesterase, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4A, dunce like phosphodiesterase E2, phosphodiesterase 4A cAMP specific, phosphodiesterase E2 dunce homolog, phosphodiesterase isozyme 4, phosphodiesterase type 4A11
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MW 275.34 Da, Purity >99%. Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively).
Key facts
- CAS number
- 61413-54-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 275.34 Da
- Molecular formula
- C16H21NO3
- PubChem identifier
- 5092
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- Rolipram
- Biological description
Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively)
- Canonical SMILES
- COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
- InChI
- InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
- InChIKey
- HJORMJIFDVBMOB-UHFFFAOYSA-N
- IUPAC name
- 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PDE4A or phosphodiesterase 4A is an isoform part of the PDE4 family known for hydrolyzing cAMP an important second messenger in cells. The mass of PDE4A can vary depending on the isoform with commonly referenced masses around 70-100 kDa. This enzyme is expressed in various tissues including the brain immune cells and lungs. Other popular names for this protein include PDE46 and DPDE2 indicating its different isoforms and specific functionalities across tissue types.
- Biological function summary
PDE4A plays an important role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) a critical component in signaling pathways that affect numerous cellular processes. By controlling cAMP concentrations PDE4A regulates inflammatory responses and airway smooth muscle contraction which is important for respiratory functions. PDE4A does not function within a complex but operates as a homodimer when exerting its effects on signaling cascades.
- Pathways
PDE4A's role is significant in the cAMP-dependent signaling pathway. This pathway influences processes like inflammation and smooth muscle relaxation. PDE4A interacts with various proteins such as PKA (protein kinase A) which is activated by cAMP and mediates several downstream effects. By influencing the cAMP pathway PDE4A affects bodily responses including immune and respiratory systems.
- Associated diseases and disorders
PDE4A has implications in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Dysregulation of cAMP through PDE4A can contribute to these respiratory conditions by affecting airway inflammation and muscle tone. PDE4A is also linked to other related proteins such as PDE4B which can also impact inflammatory pathways in similar disease contexts. PDE4 inhibitors have been explored as therapeutic agents for modifying these diseases by targeting the enzymatic activity of PDE4A and related isoforms to restore balanced cAMP levels.
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Chemical Structure - (R,S)-Rolipram, Selective PDE4 inhibitor (ab120029)
2D chemical structure image of ab120029, (R,S)-Rolipram, Selective PDE4 inhibitor
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