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AB120029

(R,S)-Rolipram, Selective PDE4 inhibitor

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(7 Publications)

MW 275.34 Da, Purity >99%. Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively).

View Alternative Names

5''-cyclic phosphodiesterase 4A, DPDE2, PDE4, PDE46, PDE4A11, PDE4A_HUMAN, Phosphodiesterase 4A, Phosphodiesterase 4A, cAMP-specific (dunce, Phosphodiesterase E2 dunce homolog, Drosophila, cAMP specific phosphodiesterase, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4A, dunce like phosphodiesterase E2, phosphodiesterase 4A cAMP specific, phosphodiesterase E2 dunce homolog, phosphodiesterase isozyme 4, phosphodiesterase type 4A11

1 Images
Chemical Structure - (R,S)-Rolipram, Selective PDE4 inhibitor (AB120029)
  • Chemical Structure

Lab

Chemical Structure - (R,S)-Rolipram, Selective PDE4 inhibitor (AB120029)

2D chemical structure image of ab120029, (R,S)-Rolipram, Selective PDE4 inhibitor

Key facts

CAS number

61413-54-5

Purity

>99%

Form

Solid

form

Molecular weight

275.34 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>1</sub>NO<sub>3</sub>

PubChem

5092

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Rolipram

Biological description

Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively)

Canonical smiles

COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

InChi

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChiKey

HJORMJIFDVBMOB-UHFFFAOYSA-N

IUPAC Name

4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE4A or phosphodiesterase 4A is an isoform part of the PDE4 family known for hydrolyzing cAMP an important second messenger in cells. The mass of PDE4A can vary depending on the isoform with commonly referenced masses around 70-100 kDa. This enzyme is expressed in various tissues including the brain immune cells and lungs. Other popular names for this protein include PDE46 and DPDE2 indicating its different isoforms and specific functionalities across tissue types.
Biological function summary

PDE4A plays an important role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) a critical component in signaling pathways that affect numerous cellular processes. By controlling cAMP concentrations PDE4A regulates inflammatory responses and airway smooth muscle contraction which is important for respiratory functions. PDE4A does not function within a complex but operates as a homodimer when exerting its effects on signaling cascades.

Pathways

PDE4A's role is significant in the cAMP-dependent signaling pathway. This pathway influences processes like inflammation and smooth muscle relaxation. PDE4A interacts with various proteins such as PKA (protein kinase A) which is activated by cAMP and mediates several downstream effects. By influencing the cAMP pathway PDE4A affects bodily responses including immune and respiratory systems.

PDE4A has implications in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Dysregulation of cAMP through PDE4A can contribute to these respiratory conditions by affecting airway inflammation and muscle tone. PDE4A is also linked to other related proteins such as PDE4B which can also impact inflammatory pathways in similar disease contexts. PDE4 inhibitors have been explored as therapeutic agents for modifying these diseases by targeting the enzymatic activity of PDE4A and related isoforms to restore balanced cAMP levels.
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

STAR protocols 3:101544 PubMed35842863

2022

Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yukiko Ishikura,Hiroshi Ohta,Masahiro Nagano,Mitinori Saitou

The EMBO journal 41:e109457 PubMed35603814

2022

Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jacqueline Severino,Moritz Bauer,Tom Mattimoe,Niccolò Arecco,Luca Cozzuto,Patricia Lorden,Norio Hamada,Yoshiaki Nosaka,So I Nagaoka,Pauline Audergon,Antonio Tarruell,Holger Heyn,Katsuhiko Hayashi,Mitinori Saitou,Bernhard Payer

Scientific reports 12:3589 PubMed35246566

2022

The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Ellis Nelissen,Nina Possemis,Nick P Van Goethem,Melissa Schepers,Danielle A J Mulder-Jongen,Lisa Dietz,Wiebke Janssen,Michael Gerisch,Jörg Hüser,Peter Sandner,Tim Vanmierlo,Jos Prickaerts

Biomedicines 9: PubMed34440254

2021

Soluble Guanylate Cyclase Stimulator Vericiguat Enhances Long-Term Memory in Rats without Altering Cerebral Blood Volume.

Applications

Unspecified application

Species

Unspecified reactive species

Ellis Nelissen,Elentina K Argyrousi,Nick P Van Goethem,Fuqiang Zhao,Catherine D G Hines,Gayathri Swaminath,Michael Gerisch,Joerg Hueser,Peter Sandner,Jos Prickaerts

Cells 10: PubMed34065927

2021

Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Faraz Ahmad,Yu Jing,Albert Lladó,Ping Liu

The EMBO journal 39:e104929 PubMed32954504

2020

Long-term expansion with germline potential of human primordial germ cell-like cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Yusuke Murase,Yukihiro Yabuta,Hiroshi Ohta,Chika Yamashiro,Tomonori Nakamura,Takuya Yamamoto,Mitinori Saitou

Science (New York, N.Y.) 327:547-52 PubMed20110498

2010

Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation.

Applications

Unspecified application

Species

Unspecified reactive species

Maya Shelly,Byung Kook Lim,Laura Cancedda,Sarah C Heilshorn,Hongfeng Gao,Mu-ming Poo
View all publications
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