MW 922.8 Da. Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.
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- FASEB journal : official publication of the Federa 33:14204-142202019Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTiziana Imbriglio et. al.PubMed 31665922
- Cell reports 28:91-103.e72019KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarie Goutierre,Sana Al Awabdh,Florian Donneger,Emeline François,Daniel Gomez-Dominguez,Theano Irinopoulou,Liset Menendez de la Prida,Jean Christophe PoncerPubMed 31269453
- Neuron 88:879-8912015A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWan-Chen Lin et. al.PubMed 26606997
- Philosophical transactions. Series A, Mathematical 371:201203302013Ruthenium polypyridyl phototriggers: from beginnings to perspectives.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLeonardo Zayat et. al.PubMed 23776299
- Proceedings of the National Academy of Sciences of the United States of America 108:15474-92011The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGrégory Gauvain,Ingrid Chamma,Quentin Chevy,Carolina Cabezas,Theano Irinopoulou,Natalia Bodrug,Michèle Carnaud,Sabine Lévi,Jean Christophe PoncerPubMed 21878564
Key facts
- CAS number
- 1028141-88-9
- Form
- Solid
- Molecular weight
- 922.8 Da
- Molecular formula
- C42H39F6N5O2P2Ru
- PubChem identifier
- 129316180
- Nature
- Synthetic
Target data
Recommended products
MW 922.8 Da. Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.
Key facts
- CAS number
- 1028141-88-9
- Form
- Solid
- Molecular weight
- 922.8 Da
- Molecular formula
- C42H39F6N5O2P2Ru
- PubChem identifier
- 129316180
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
For water solubility, please refer to Guideline for Use Information Sheet.
- Biochemical name
- RuBi-GABA
- Biological description
Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.
- Canonical SMILES
- C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=NC(=C1)C2=CC=CC=N2.C1=CC=NC(=C1)C2=CC=CC=N2.C(CC(=O)[O-])CN.F[P-](F)(F)(F)(F)F.[Ru+2]
- InChI
- InChI=1S/C18H15P.2C10H8N2.C4H9NO2.F6P.Ru/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;2*1-3-7-11-9(5-1)10-6-2-4-8-12-10;5-3-1-2-4(6)7;1-7(2,3,4,5)6;/h1-15H;2*1-8H;1-3,5H2,(H,6,7);;/q;;;;-1;+2/p-1
- InChIKey
- SWFWLLYVSYURHZ-UHFFFAOYSA-M
- IUPAC name
- 4-aminobutanoate;2-pyridin-2-ylpyridine;ruthenium(2+);triphenylphosphane;hexafluorophosphate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
Notes
RuBi-GABA is light sensitive and it is recommended that the compound is protected from light.
Sold under license from Columbia University; Patent Pending.
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1 product image
Chemical Structure - RuBi-GABA, caged-GABA compound (ab120409)
2D chemical structure image of ab120409, RuBi-GABA, caged-GABA compound
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