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AB144347

Rubratoxin A, PP2A inhibitor

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MW 520.5 Da, Purity >95%. Potent, selective, competitive PP2A inhibitor (Ki = 28.7 nM). Rubratoxin B analog. Induces caspase-dependent decrease in cell viability. Shows antitumor effects in vivo. .
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Chemical Structure - Rubratoxin A, PP2A inhibitor (AB144347)
  • Chemical Structure

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Chemical Structure - Rubratoxin A, PP2A inhibitor (AB144347)

2D chemical structure image of ab144347, Rubratoxin A, PP2A inhibitor

Key facts

CAS number

22467-31-8

Purity

>95%

Form

Solid

form

Source

Penicillium sp.

Molecular weight

520.5 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>2</sub>O<sub>1</sub><sub>1</sub>

PubChem

56840856

Nature

Native

Solubility

Soluble in ethanol

Soluble in DMSO

Biochemical name

Rubratoxin A

Biological description

Potent, selective, competitive PP2A inhibitor (Ki = 28.7 nM). Rubratoxin B analog. Induces caspase-dependent decrease in cell viability. Shows antitumor effects in vivo.

Canonical smiles

CCCCCCC(C1C(C2=C(CC(CC3=C1C(=O)OC3O)C(C4CC=CC(=O)O4)O)C(=O)OC2=O)O)O

Isomeric smiles

CCCCCC[C@@H](C1[C@@H](C2=C(CC(CC3=C1C(=O)OC3O)[C@@H](C4CC=CC(=O)O4)O)C(=O)OC2=O)O)O

InChi

InChI=1S/C26H32O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-23,27,29-31H,2-5,7-8,10-11H2,1H3/t12?,15-,16?,20?,21-,22+,23?/m0/s1

InChiKey

XOEFANNJIKAWGX-MQXBNGFTSA-N

IUPAC Name

(3S)-3,13-dihydroxy-2-[(1S)-1-hydroxyheptyl]-10-[(S)-hydroxy-(6-oxo-2,3-dihydropyran-2-yl)methyl]-6,14-dioxatricyclo[10.3.0.04,8]pentadeca-1(12),4(8)-diene-5,7,15-trione

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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