MW 790.4 Da. Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels.
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- Antioxidants (Basel, Switzerland) 11:2022Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJisoo Song,Gwonhwa Song,Sunwoo Park,Whasun LimPubMed 35052675
- Pesticide biochemistry and physiology 163:84-932020Ivermectin-induced programmed cell death and disruption of mitochondrial membrane potential in bovine mammary gland epithelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHahyun Park,Gwonhwa Song,Whasun LimPubMed 31973874
- Carbohydrate polymers 225:1152362019Dextran as an elicitor of phenylpropanoid and flavonoid biosynthesis in tomato fruit against gray mold infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLaifeng Lu et. al.PubMed 31521274
- Molecular cell 67:711-723.e72017Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniela M Arduino,Jennifer Wettmarshausen,Horia Vais,Paloma Navas-Navarro,Yiming Cheng,Anja Leimpek,Zhongming Ma,Alba Delrio-Lorenzo,Andrea Giordano,Cecilia Garcia-Perez,Guillaume Médard,Bernhard Kuster,Javier García-Sancho,Dejana Mokranjac,J Kevin Foskett,M Teresa Alonso,Fabiana PerocchiPubMed 28820965
- PloS one 12:e01724912017Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLea Weber et. al.PubMed 28273117
- The Journal of neuroscience : the official journal of the Society for Neuroscience 31:7089-1012011The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel A Ryskamp,Paul Witkovsky,Peter Barabas,Wei Huang,Christopher Koehler,Nikolay P Akimov,Suk Hee Lee,Shiwani Chauhan,Wei Xing,René C Rentería,Wolfgang Liedtke,David KrizajPubMed 21562271
Key facts
- Form
- Solid
- Molecular weight
- 790.4 Da
- Molecular formula
- Cl6H46N14O2Ru3
- PubChem identifier
- 16218584
- Nature
- Synthetic
Recommended products
MW 790.4 Da. Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels.
Key facts
- Form
- Solid
- Molecular weight
- 790.4 Da
- Molecular formula
- Cl6H46N14O2Ru3
- PubChem identifier
- 16218584
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
- Biochemical name
- Ammoniated ruthenium oxychloride
- Biological description
Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels
- Canonical SMILES
- N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]
- InChI
- InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
- InChIKey
- JQJSTVUROJELSR-UHFFFAOYSA-H
- IUPAC name
- azane;ruthenium(2+);hexachloride;dihydrate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (ab120264)
2D chemical structure image of ab120264, Ruthenium red, Ca2+ signaling inhibitor
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