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AB120264

Ruthenium red, Ca2+ signaling inhibitor

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(7 Publications)

MW 790.4 Da. Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels.
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Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (AB120264)
  • Chemical Structure

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Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (AB120264)

2D chemical structure image of ab120264, Ruthenium red, Ca2+ signaling inhibitor

Key facts

Form

Solid

form

Molecular weight

790.4 Da

Molecular formula

Cl<sub>6</sub>H<sub>4</sub><sub>6</sub>N<sub>1</sub><sub>4</sub>O<sub>2</sub>Ru<sub>3</sub>

PubChem

16218584

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Biochemical name

Ammoniated ruthenium oxychloride

Biological description

Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels

Canonical smiles

N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]

InChi

InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6

InChiKey

JQJSTVUROJELSR-UHFFFAOYSA-H

IUPAC Name

azane;ruthenium(2+);hexachloride;dihydrate

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB141871

GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor

Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

  • 5
  • 1
Biochemicals

AB120914

Xestospongin C, IP3 receptor antagonist

Chemical Structure - Xestospongin C, IP3 receptor antagonist (AB120914)

  • 0
  • 0
Assay Kits

AB112129

Calcium Flux Assay Kit (Fluo-8, No Wash)

Functional Studies - Calcium Flux Assay Kit (Fluo-8, No Wash) (AB112129)

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  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:6751 PubMed38514795

2024

MCU-independent Ca uptake mediates mitochondrial Ca overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Bround,Eaman Abay,Jiuzhou Huo,Julian R Havens,Allen J York,Donald M Bers,Jeffery D Molkentin

Antioxidants (Basel, Switzerland) 11: PubMed35052675

2022

Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function.

Applications

Unspecified application

Species

Unspecified reactive species

Jisoo Song,Gwonhwa Song,Sunwoo Park,Whasun Lim

Pesticide biochemistry and physiology 163:84-93 PubMed31973874

2020

Ivermectin-induced programmed cell death and disruption of mitochondrial membrane potential in bovine mammary gland epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hahyun Park,Gwonhwa Song,Whasun Lim

Carbohydrate polymers 225:115236 PubMed31521274

2019

Dextran as an elicitor of phenylpropanoid and flavonoid biosynthesis in tomato fruit against gray mold infection.

Applications

Unspecified application

Species

Unspecified reactive species

Laifeng Lu,Lifeng Ji,Ruixi Shi,Shuhua Li,Xi Zhang,Qingbin Guo,Changlu Wang,Liping Qiao

Molecular cell 67:711-723.e7 PubMed28820965

2017

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela M Arduino,Jennifer Wettmarshausen,Horia Vais,Paloma Navas-Navarro,Yiming Cheng,Anja Leimpek,Zhongming Ma,Alba Delrio-Lorenzo,Andrea Giordano,Cecilia Garcia-Perez,Guillaume Médard,Bernhard Kuster,Javier García-Sancho,Dejana Mokranjac,J Kevin Foskett,M Teresa Alonso,Fabiana Perocchi

PloS one 12:e0172491 PubMed28273117

2017

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Lea Weber,Klaudia Al-Refae,Juliane Ebbert,Peter Jägers,Janine Altmüller,Christian Becker,Stephan Hahn,Günter Gisselmann,Hanns Hatt

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:7089-101 PubMed21562271

2011

The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel A Ryskamp,Paul Witkovsky,Peter Barabas,Wei Huang,Christopher Koehler,Nikolay P Akimov,Suk Hee Lee,Shiwani Chauhan,Wei Xing,René C Rentería,Wolfgang Liedtke,David Krizaj
View all publications
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