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MW 306.4 Da, Purity >99%. Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC50 values of 3.3, 2.8 and 428 nM for JAK1, JAK2 and JAK3 respectively in vitro). Inhibits IL-6 signaling (IC50 = 281nM). Orally bioavailable.

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Publications

Key facts

CAS number
941678-49-5
Purity
> 99%
Form
Solid
Molecular weight
306.4 Da
Molecular formula
C17H18N6
PubChem identifier
25126798
Nature
Synthetic

Target data

Recommended products

MW 306.4 Da, Purity >99%. Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC50 values of 3.3, 2.8 and 428 nM for JAK1, JAK2 and JAK3 respectively in vitro). Inhibits IL-6 signaling (IC50 = 281nM). Orally bioavailable.

Key facts

Purity
> 99%
PubChem identifier
25126798
Solubility

Soluble in DMSO to 16 mM.

Soluble in ethanol to 32 mM.

Biochemical name
Ruxolitinib
Biological description

Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC50 values of 3.3, 2.8 and 428 nM for JAK1, JAK2 and JAK3 respectively in vitro). Inhibits IL-6 signaling (IC50 = 281nM). Orally bioavailable.

Canonical SMILES
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Isomeric SMILES
C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChI
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChIKey
HFNKQEVNSGCOJV-OAHLLOKOSA-N
IUPAC name
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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