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AB141729

RWJ-60475 (AM)3, CD45 tyrosine phosphatase inhibitor

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(1 Publication)

MW 620.4 g/mol, Purity >95%. CD45 tyrosine phosphatase inhibitor (IC50 = 2 μM). Cell permeable. Inhibits ADP induced platelet aggregation and IL-2 production in vitro.
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Chemical Structure - RWJ-60475 (AM)3, CD45 tyrosine phosphatase inhibitor (AB141729)
  • Chemical Structure

Lab

Chemical Structure - RWJ-60475 (AM)3, CD45 tyrosine phosphatase inhibitor (AB141729)

2D chemical structure image of ab141729, RWJ-60475 (AM)3, CD45 tyrosine phosphatase inhibitor

Key facts

Purity

>95%

Form

Solid

form

Molecular weight

620.4 g/mol

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>3</sub>BrNO<sub>1</sub><sub>3</sub>P

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biological description

CD45 tyrosine phosphatase inhibitor (IC50 = 2 μM). Cell permeable. Inhibits ADP induced platelet aggregation and IL-2 production in vitro.

Canonical smiles

BRC2CCC(OC1CCC(CC1C(OCOC(C)=O)P(=O)(OCOC(C)=O)OCOC(C)=O)[N+]([O-])=O)CC2

InChi

InChI=1S/C22H23BrNO13P/c1-14(25)31-11-34-22(38(30,35-12-32-15(2)26)36-13-33-16(3)27)20-10-18(24(28)29)6-9-21(20)37-19-7-4-17(23)5-8-19/h4-10,22H,11-13H2,1-3H3

InChiKey

LKUULZRZILWDKJ-UHFFFAOYSA-N

IUPAC Name

2-(4-Bromophenoxy)-5-nitrophenylhydroxymethylphosphonic acid tris(acetoxymethyl) ester

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Developmental cell 31:420-33 PubMed25458010

2014

DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.

Applications

Unspecified application

Species

Unspecified reactive species

Stefano Marchesi,Francesca Montani,Gianluca Deflorian,Rocco D'Antuono,Alessandro Cuomo,Serena Bologna,Carmela Mazzoccoli,Tiziana Bonaldi,Pier Paolo Di Fiore,Francesco Nicassio
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