AB120083

Ryanodine, Ca2+ release modulator

Name: Ryanodine, Ca2+ release modulator (CAS 15662-33-6) | Abcam
Brand: Abcam Limited
SKU: AB120083
Price: 210 USD
Availability: InStock

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(39 Publications)

MW 493.5 Da, Purity >98%. Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.

2 Images

Functional Studies - Ryanodine, Ca2+ release modulator (AB120083)

FuncS

PubMed

Functional Studies - Ryanodine, Ca2+ release modulator (AB120083)

Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.

Image from Touchberry CD et al., J Biol Chem. 2010;285(51):40312-21. Fig 4(A-B).; doi: 10.1074/jbc.M110.179689.

Chemical Structure - Ryanodine, Ca2+ release modulator (AB120083)

Chemical Structure

Lab

Chemical Structure - Ryanodine, Ca2+ release modulator (AB120083)

2D chemical structure image of ab120083, Ryanodine, Ca2+ release modulator

Key facts

CAS number

15662-33-6

Purity

>98%

Form

Solid

form

Source

Ryania speciosa

Molecular weight

493.5 Da

Molecular formula

C25H35NO9

PubChem

5114

Nature

Native

Solubility

Soluble in ethanol to 10 mM

Biochemical name

1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

Biological description

Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.

Canonical smiles

CC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O

InChi

InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3

InChiKey

JJSYXNQGLHBRRK-UHFFFAOYSA-N

IUPAC Name

(2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl) 1H-pyrrole-2-carboxylate

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (39)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 12:e70152 PubMed39715724

2024

Induction of cardiac alternans in human iPS-derived cardiomyocytes through β-adrenergic receptor stimulation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuto Hinata,Daisuke Sasaki,Katsuhisa Matsuura,Tatsuya Shimizu

Molecular neurobiology 62:4115-4138 PubMed39397241

2024

Involvement of BK Channels and Ryanodine Receptors in Salicylate-induced Tinnitus.

Applications

Unspecified application

Species

Unspecified reactive species

Wenying Shi,Qi Zhao,Hongwei Gao,Chao Yang,Zhiyong Tan,Na Li,Feng Jiang,Hongjie Wang,Yonghua Ji,You Zhou

Signal transduction and targeted therapy 8:22 PubMed36658134

2023

Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1.

Applications

Unspecified application

Species

Unspecified reactive species

Keke Wei,Huafeng Zhang,Shuaishuai Yang,Yuxiao Cui,Bingxia Zhang,Jincheng Liu,Liang Tang,Yaoyao Tan,Simin Liu,Shiqi Chen,Wu Yuan,Xiao Luo,Chen Chen,Fei Li,Junwei Liu,Jie Chen,Pingwei Xu,Jiadi Lv,Ke Tang,Yi Zhang,Jingwei Ma,Bo Huang

Cell reports 30:3466-3477.e4 PubMed32160550

2020

Local Resting Ca Controls the Scale of Astroglial Ca Signals.

Applications

Unspecified application

Species

Unspecified reactive species

Claire M King,Kirsten Bohmbach,Daniel Minge,Andrea Delekate,Kaiyu Zheng,James Reynolds,Cordula Rakers,Andre Zeug,Gabor C Petzold,Dmitri A Rusakov,Christian Henneberger

Cell reports 28:2427-2442.e6 PubMed31461656

2019

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Giriraj Sahu,Rima-Marie Wazen,Pina Colarusso,S R Wayne Chen,Gerald W Zamponi,Ray W Turner

Neuroscience 416:268-280 PubMed31425734

2019

ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Chen,Jie Zhu,Yu-Hai Wang,Chun-Hua Hang

The FEBS journal 286:4356-4373 PubMed31230413

2019

Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Rongjin Luo,Yu Song,Zhiwei Liao,Huipeng Yin,Shengfeng Zhan,Kun Wang,Shuai Li,Gaocai Li,Liang Ma,Saideng Lu,Yukun Zhang,Cao Yang

Arteriosclerosis, thrombosis, and vascular biology 38:2217-2224 PubMed30026269

2018

Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.

Applications

Unspecified application

Species

Unspecified reactive species

Emanuel Harari,Liang Guo,Samantha L Smith,Ka Hyun Paek,Raquel Fernandez,Atsushi Sakamoto,Hiroyoshi Mori,Matthew D Kutyna,Anwer Habib,Sho Torii,Anne Cornelissen,Hiroyuki Jinnouchi,Anuj Gupta,Frank D Kolodgie,Renu Virmani,Aloke V Finn

BioMed research international 2018:2925985 PubMed29511675

2018

Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.

Applications

Unspecified application

Species

Unspecified reactive species

Mingshuai Wang,Nianzeng Xing,Liyang Wu,Wen-Chu Huang,Zhenqun Xu,Guiming Liu

Cell 167:145-157.e17 PubMed27662087

2016

Structural Basis for Gating and Activation of RyR1.

Applications

Unspecified application

Species

Unspecified reactive species

Amédée des Georges,Oliver B Clarke,Ran Zalk,Qi Yuan,Kendall J Condon,Robert A Grassucci,Wayne A Hendrickson,Andrew R Marks,Joachim Frank

View all publications

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Ryanodine, Ca2+ release modulator

Functional Studies - Ryanodine, Ca2+ release modulator (AB120083)

Chemical Structure - Ryanodine, Ca2+ release modulator (AB120083)

Key facts

CAS number

Purity

Form

Source

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (39)

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