MW 493.5 Da, Purity >98%. Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.
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- Signal transduction and targeted therapy 8:222023Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKeke Wei,Huafeng Zhang,Shuaishuai Yang,Yuxiao Cui,Bingxia Zhang,Jincheng Liu,Liang Tang,Yaoyao Tan,Simin Liu,Shiqi Chen,Wu Yuan,Xiao Luo,Chen Chen,Fei Li,Junwei Liu,Jie Chen,Pingwei Xu,Jiadi Lv,Ke Tang,Yi Zhang,Jingwei Ma,Bo HuangPubMed 36658134
- Cell reports 30:3466-3477.e42020Local Resting Ca Controls the Scale of Astroglial Ca Signals.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClaire M King,Kirsten Bohmbach,Daniel Minge,Andrea Delekate,Kaiyu Zheng,James Reynolds,Cordula Rakers,Andre Zeug,Gabor C Petzold,Dmitri A Rusakov,Christian HennebergerPubMed 32160550
- Cell reports 28:2427-2442.e62019Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiriraj Sahu,Rima-Marie Wazen,Pina Colarusso,S R Wayne Chen,Gerald W Zamponi,Ray W TurnerPubMed 31461656
- Neuroscience 416:268-2802019ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTao Chen et. al.PubMed 31425734
- The FEBS journal 286:4356-43732019Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRongjin Luo,Yu Song,Zhiwei Liao,Huipeng Yin,Shengfeng Zhan,Kun Wang,Shuai Li,Gaocai Li,Liang Ma,Saideng Lu,Yukun Zhang,Cao YangPubMed 31230413
- Arteriosclerosis, thrombosis, and vascular biology 38:2217-22242018Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief Report.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmanuel Harari,Liang Guo,Samantha L Smith,Ka Hyun Paek,Raquel Fernandez,Atsushi Sakamoto,Hiroyoshi Mori,Matthew D Kutyna,Anwer Habib,Sho Torii,Anne Cornelissen,Hiroyuki Jinnouchi,Anuj Gupta,Frank D Kolodgie,Renu Virmani,Aloke V FinnPubMed 30026269
- BioMed research international 2018:29259852018Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMingshuai Wang et. al.PubMed 29511675
- Cell 167:145-157.e172016Structural Basis for Gating and Activation of RyR1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmédée des Georges,Oliver B Clarke,Ran Zalk,Qi Yuan,Kendall J Condon,Robert A Grassucci,Wayne A Hendrickson,Andrew R Marks,Joachim FrankPubMed 27662087
- eLife 5:2016The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAbigail G Garrity et. al.PubMed 27213518
- Journal of neurochemistry 133:309-192015Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaría Guerra-Álvarez et. al.PubMed 25650007
Key facts
- CAS number
- 15662-33-6
- Purity
- > 98%
- Form
- Solid
- Source
- Ryania speciosa
- Molecular weight
- 493.5 Da
- Molecular formula
- C25H35NO9
- PubChem identifier
- 5114
- Nature
- Native
Target data
Recommended products
MW 493.5 Da, Purity >98%. Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.
Key facts
- CAS number
- 15662-33-6
- Purity
- > 98%
- Form
- Solid
- Source
- Ryania speciosa
- Molecular weight
- 493.5 Da
- Molecular formula
- C25H35NO9
- PubChem identifier
- 5114
- Nature
- Native
- Solubility
Soluble in ethanol to 10 mM.
- Biochemical name
- 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
- Biological description
Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.
- Canonical SMILES
- CC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
- InChI
- InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3
- InChIKey
- JJSYXNQGLHBRRK-UHFFFAOYSA-N
- IUPAC name
- (2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl) 1H-pyrrole-2-carboxylate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Ryanodine, Ca2+ release modulator (ab120083)
2D chemical structure image of ab120083, Ryanodine, Ca2+ release modulator
Image from Touchberry CD et al., J Biol Chem. 2010;285(51):40312-21. Fig 4(A-B).; doi: 10.1074/jbc.M110.179689.Functional Studies - Ryanodine, Ca2+ release modulator (ab120083)
Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.
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