MW 480.43 g/mol, Purity >97%.
Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.
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Publications
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- The Journal of cell biology 222:2023Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElin Larsson,Björn Morén,Kerrie-Ann McMahon,Robert G Parton,Richard LundmarkPubMed 36729022
- Frontiers in cell and developmental biology 10:8845092022The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEriko Hamasaki,Natsuki Wakita,Hiroki Yasuoka,Hikaru Nagaoka,Masayuki Morita,Eizo Takashima,Takayuki Uchihashi,Tetsuya Takeda,Tadashi Abe,Ji-Won Lee,Tadahiro Iimura,Moin A Saleem,Naohisa Ogo,Akira Asai,Akihiro Narita,Kohji Takei,Hiroshi YamadaPubMed 35620056
- Molecular psychiatry 20:810-92015Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJ Jackson et. al.PubMed 25939402
- Biochimica et biophysica acta 1853:611-82014Role of dynamin in elongated cell migration in a 3D matrix.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJustin G Lees,Nick N Gorgani,Alaina J Ammit,Adam McCluskey,Phillip J Robinson,Geraldine M O'NeillPubMed 25498249
- Traffic (Copenhagen, Denmark) 15:819-382014Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChangkyu Gu,Joann Chang,Valentina A Shchedrina,Vincent A Pham,John H Hartwig,Worawit Suphamungmee,William Lehman,Bradley T Hyman,Brian J Bacskai,Sanja SeverPubMed 24891099
- PLoS pathogens 6:e10008662010A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKerrie J Sandgren et. al.PubMed 20421949
Key facts
- CAS number
171674-76-3
- Purity
> 97%
- Form
Lyophilized
- Molecular weight
480.43 g/mol
- Nature
Synthetic
Recommended products
MW 480.43 g/mol, Purity >97%.
Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.
.
Key facts
- CAS number
171674-76-3
- Purity
> 97%
- Form
Lyophilized
- Molecular weight
480.43 g/mol
- Nature
Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biological description
Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.
- Isomeric SMILES
OC2CC(\C=C(/C#N)C(=O)NCCCNC(=O)C(\C#N)=C\C1CC(O)C(O)C(O)C1)CC(O)C2O
- IUPAC name
(2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store in the dark, Store under desiccating conditions
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1 product image
Chemical Structure - Ryngo® 1-23, Dynamin activator (ab146050)
2D chemical structure image of ab146050, Ryngo® 1-23, Dynamin activator
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