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AB146050

Ryngo® 1-23, Dynamin activator

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(4 Publications)

MW 480.43 g/mol, Purity >97%.

Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.

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Chemical Structure - Ryngo® 1-23, Dynamin activator (AB146050)
  • Chemical Structure

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Chemical Structure - Ryngo® 1-23, Dynamin activator (AB146050)

2D chemical structure image of ab146050, Ryngo® 1-23, Dynamin activator

Key facts

CAS number

171674-76-3

Purity

>97%

Form

Lyophilized

form

Molecular weight

480.43 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biological description

Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.

Isomeric smiles

OC2CC(\C=C(/C#N)C(=O)NCCCNC(=O)C(\C#N)=C\C1CC(O)C(O)C(O)C1)CC(O)C2O

IUPAC Name

(2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 222: PubMed36729022

2023

Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization.

Applications

Unspecified application

Species

Unspecified reactive species

Elin Larsson,Björn Morén,Kerrie-Ann McMahon,Robert G Parton,Richard Lundmark

Frontiers in cell and developmental biology 10:884509 PubMed35620056

2022

The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Eriko Hamasaki,Natsuki Wakita,Hiroki Yasuoka,Hikaru Nagaoka,Masayuki Morita,Eizo Takashima,Takayuki Uchihashi,Tetsuya Takeda,Tadashi Abe,Ji-Won Lee,Tadahiro Iimura,Moin A Saleem,Naohisa Ogo,Akira Asai,Akihiro Narita,Kohji Takei,Hiroshi Yamada

Molecular psychiatry 20:810-9 PubMed25939402

2015

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.

Applications

Unspecified application

Species

Unspecified reactive species

J Jackson,A Papadopulos,F A Meunier,A McCluskey,P J Robinson,D J Keating

Biochimica et biophysica acta 1853:611-8 PubMed25498249

2014

Role of dynamin in elongated cell migration in a 3D matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Justin G Lees,Nick N Gorgani,Alaina J Ammit,Adam McCluskey,Phillip J Robinson,Geraldine M O'Neill
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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