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AB120006

(S)-3,4-DCPG (UBP1109), mGlu8a agonist

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(3 Publications)

MW 239.18 Da, Purity >99%. Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays >100-fold selectivity over mGlu1-7. Systemically active in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

View Alternative Names

FLJ41058, G protein coupled receptor family C group 1 member F, GLUR, GLUR8, GPRC1A, GPRC1D, GPRC1F, GPRC1H, GRM1-Alpha, GRM1_HUMAN, GRM4_HUMAN, GRM8_HUMAN, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 8, MGC126724, MGLU1, MGLUR6, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 6 precursor, Metabotropic glutamate receptor 8, SCAR13, Smp_128940, mGlu4, mGlu6, mGlu8, mGluR1, mGluR4

1 Images
Chemical Structure - (S)-3,4-DCPG (UBP1109), mGlu8a agonist (AB120006)
  • Chemical Structure

Lab

Chemical Structure - (S)-3,4-DCPG (UBP1109), mGlu8a agonist (AB120006)

2D chemical structure image of ab120006, (S)-3,4-DCPG (UBP1109), mGlu8a agonist

Key facts

CAS number

201730-11-2

Purity

>99%

Form

Solid

form

Molecular weight

239.18 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>9</sub>NO<sub>6</sub>

PubChem

16062593

Nature

Synthetic

Biochemical name

4-[(S)-Amino(carboxy)methyl]benzene-1,2-dicarboxylic acid

Biological description

Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays >100-fold selectivity over mGlu1-7. Systemically active in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O

Isomeric smiles

C1=CC(=C(C=C1[C@@H](C(=O)O)N)C(=O)O)C(=O)O

InChi

InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

InChiKey

IJVMOGKBEVRBPP-ZETCQYMHSA-N

IUPAC Name

4-[(S)-amino(carboxy)methyl]phthalic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Neuropsychopharmacology : official publication of 36:1599-607 PubMed21451497

2011

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Heather B Gosnell,Yuval Silberman,Brad A Grueter,Robert M Duvoisin,Jacob Raber,Danny G Winder

FASEB journal : official publication of the Federa 23:3619-28 PubMed19525404

2009

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

Applications

Unspecified application

Species

Unspecified reactive species

Corinne Beurrier,Sebastien Lopez,Delphine Révy,Chelliah Selvam,Cyril Goudet,Morgane Lhérondel,Paolo Gubellini,Lydia Kerkerian-LeGoff,Francine Acher,Jean-Philippe Pin,Marianne Amalric

The Journal of neuroscience : the official journal of the Society for Neuroscience 27:6701-11 PubMed17581957

2007

Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastien Lopez,Nathalie Turle-Lorenzo,Francine Acher,Elvira De Leonibus,Andrea Mele,Marianne Amalric
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