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AB120007

(S)-3,5-DHPG, group I mGlu agonist

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(30 Publications)

MW 183.16 Da, Purity >99%. Selective group I mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, FLJ40498, FLJ41058, G protein coupled receptor family C group 1 member F, GLUR, GLUR8, GPRC1A, GPRC1B, GPRC1C, GPRC1D, GPRC1E, GPRC1F, GPRC1G, GPRC1H, GRM1-Alpha, GRM1_HUMAN, GRM4_HUMAN, GRM5_HUMAN, GRM7_HUMAN, GRM8_HUMAN, GluR-2, GluR-3, GluR-7, Glucocorticoid inducible P450, Glutamate receptor homolog, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 5, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 7, Glutamate receptor metabotropic 8, HLP, MGC126680, MGC126724, MGLU1, MGLU7, MGLUR2, MGLUR3, MGLUR6, MGlu3, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Metabotropic glutamate receptor 6 precursor, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 8, NF 25, Nifedipine oxidase, OTTHUMP00000206961, OTTHUMP00000214674, OTTHUMP00000214675, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PPP1R86, Protein phosphatase 1 regulatory subunit 86, Quinine 3-monooxygenase, SCAR13, Smp_128940, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, mGlu2, mGlu4, mGlu5, mGlu6, mGlu8, mGluR1, mGluR4, mGluR5, mGluR7

2 Images
Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)
  • FuncS

Unknown

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

SK-N-SH cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of (S)-3,5-DHPG (ab120007). Increased expression of CREB (phospho S133) in SK-N-SH cells correlates with an increase (S)-3,5-DHPG concentration, as described in literature.

Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab32096 at 1/500 dilution and ab32515 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (AB120007)
  • Chemical Structure

Lab

Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

2D chemical structure image of ab120007, (S)-3,5-DHPG, group I mGlu agonist

Key facts

CAS number

162870-29-3

Purity

>99%

Form

Solid

form

Molecular weight

183.16 Da

Molecular formula

C<sub>8</sub>H<sub>9</sub>NO<sub>4</sub>

PubChem

443586

Nature

Synthetic

Biochemical name

(S)-3,5-Dihydroxyphenylglycine

Biological description

Selective group I mGlu agonist.

Canonical smiles

C1=C(C=C(C=C1O)O)C(C(=O)O)N

Isomeric smiles

C1=C(C=C(C=C1O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1

InChiKey

HOOWCUZPEFNHDT-ZETCQYMHSA-N

IUPAC Name

(2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Product protocols

Publications (30)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:108412 PubMed38053635

2023

Amyloid-β oligomers enhance mGluR-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ai Na Ng,Eric W Salter,John Georgiou,Zuner A Bortolotto,Graham L Collingridge

Nature communications 13:5272 PubMed36071061

2022

Ca-modulated photoactivatable imaging reveals neuron-astrocyte glutamatergic circuitries within the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Serra,Julio Esparza,Laura Delgado,Cristina Martín-Monteagudo,Margalida Puigròs,Petar Podlesniy,Ramón Trullás,Marta Navarrete

Biology of reproduction 107:916-927 PubMed35746896

2022

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan Čikoš

Cell reports 37:109805 PubMed34644573

2021

Correction of amygdalar dysfunction in a rat model of fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Giselle Fernandes,Pradeep K Mishra,Mohammad Sarfaraz Nawaz,Paul G Donlin-Asp,Mohammed Mostafizur Rahman,Anupam Hazra,Sonal Kedia,Aiman Kayenaat,Dheeraj Songara,David J A Wyllie,Erin M Schuman,Peter C Kind,Sumantra Chattarji

Journal of neurochemistry 158:1094-1109 PubMed34327719

2021

Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Rohini Subrahmanyam,Deepanjali Dwivedi,Zubin Rashid,Katherine Bonnycastle,Michael A Cousin,Sumantra Chattarji

Function (Oxford, England) 2:zqab012 PubMed35330679

2021

A New Transgenic Mouse Line for Imaging Mitochondrial Calcium Signals.

Applications

Unspecified application

Species

Unspecified reactive species

Nelly Redolfi,Elisa Greotti,Giulia Zanetti,Tino Hochepied,Cristina Fasolato,Diana Pendin,Tullio Pozzan

Cell reports 28:11-20.e9 PubMed31269433

2019

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Applications

Unspecified application

Species

Unspecified reactive species

Wolfgang Wagner,Kristina Lippmann,Frank F Heisler,Kira V Gromova,Franco L Lombino,Mona K Roesler,Yvonne Pechmann,Sönke Hornig,Michaela Schweizer,Simona Polo,Jürgen R Schwarz,Jens Eilers,Matthias Kneussel

Nature communications 8:1103 PubMed29062097

2017

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.

Applications

Unspecified application

Species

Unspecified reactive species

Elisabetta Aloisi,Katy Le Corf,Julien Dupuis,Pei Zhang,Melanie Ginger,Virginie Labrousse,Michela Spatuzza,Matthias Georg Haberl,Lara Costa,Ryuichi Shigemoto,Anke Tappe-Theodor,Filippo Drago,Pier Vincenzo Piazza,Christophe Mulle,Laurent Groc,Lucia Ciranna,Maria Vincenza Catania,Andreas Frick

Scientific reports 6:28454 PubMed27345695

2016

Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Michelangelo Colavita,Geoffrey Terral,Clement E Lemercier,Filippo Drago,Giovanni Marsicano,Federico Massa

Frontiers in cellular neuroscience 9:367 PubMed26441538

2015

Tracking the activity-dependent diffusion of synaptic proteins using restricted photoconversion of Dendra2.

Applications

Unspecified application

Species

Unspecified reactive species

Frédéric Cassé,Stéphane Martin
View all publications

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