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MW 183.16 Da, Purity >99%. Selective group I mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (AB120007), expandable thumbnail
  • Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007), expandable thumbnail

Publications

Key facts

CAS number
162870-29-3
Purity
> 99%
Form
Solid
Molecular weight
183.16 Da
Molecular formula
C8H9NO4
PubChem identifier
443586
Nature
Synthetic

Target data

Alternative names

1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, FLJ40498, FLJ41058, G protein coupled receptor family C group 1 member F, GLUR, GLUR8, GPRC1A, GPRC1B, GPRC1C, GPRC1D, GPRC1E, GPRC1F, GPRC1G, GPRC1H, GRM1-Alpha, GRM1_HUMAN, GRM4_HUMAN, GRM5_HUMAN, GRM7_HUMAN, GRM8_HUMAN, GluR-2, GluR-3, GluR-7, Glucocorticoid inducible P450, Glutamate receptor homolog, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 5, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 7, Glutamate receptor metabotropic 8, HLP, MGC126680, MGC126724, MGLU1, MGLU7, MGLUR2, MGLUR3, MGLUR6, MGlu3, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Metabotropic glutamate receptor 6 precursor, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 8, NF 25, Nifedipine oxidase, OTTHUMP00000206961, OTTHUMP00000214674, OTTHUMP00000214675, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PPP1R86, Protein phosphatase 1 regulatory subunit 86, Quinine 3-monooxygenase, SCAR13, Smp_128940, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, mGlu2, mGlu4, mGlu5, mGlu6, mGlu8, mGluR1, mGluR4, mGluR5, mGluR7

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MW 183.16 Da, Purity >99%. Selective group I mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity
> 99%
PubChem identifier
443586
Biochemical name
(S)-3,5-Dihydroxyphenylglycine
Biological description

Selective group I mGlu agonist.

Canonical SMILES
C1=C(C=C(C=C1O)O)C(C(=O)O)N
Isomeric SMILES
C1=C(C=C(C=C1O)O)[C@@H](C(=O)O)N
InChI
InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1
InChIKey
HOOWCUZPEFNHDT-ZETCQYMHSA-N
IUPAC name
(2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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2 product images

  • Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (ab120007), expandable thumbnail

    Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (ab120007)

    2D chemical structure image of ab120007, (S)-3,5-DHPG, group I mGlu agonist

  • Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (ab120007), expandable thumbnail

    Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (ab120007)

    SK-N-SH cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of (S)-3,5-DHPG (ab120007). Increased expression of CREB (phospho S133) in SK-N-SH cells correlates with an increase (S)-3,5-DHPG concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with Anti-CREB (phospho S133) antibody [E113] ab32096 at 1/500 dilution and Anti-CREB antibody [E306] ab32515 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.

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