(S)-3,5-DHPG, group I mGlu agonist
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(30 Publications)
MW 183.16 Da, Purity >99%. Selective group I mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.
View Alternative Names
1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, FLJ40498, FLJ41058, G protein coupled receptor family C group 1 member F, GLUR, GLUR8, GPRC1A, GPRC1B, GPRC1C, GPRC1D, GPRC1E, GPRC1F, GPRC1G, GPRC1H, GRM1-Alpha, GRM1_HUMAN, GRM4_HUMAN, GRM5_HUMAN, GRM7_HUMAN, GRM8_HUMAN, GluR-2, GluR-3, GluR-7, Glucocorticoid inducible P450, Glutamate receptor homolog, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 5, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 7, Glutamate receptor metabotropic 8, HLP, MGC126680, MGC126724, MGLU1, MGLU7, MGLUR2, MGLUR3, MGLUR6, MGlu3, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Metabotropic glutamate receptor 6 precursor, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 8, NF 25, Nifedipine oxidase, OTTHUMP00000206961, OTTHUMP00000214674, OTTHUMP00000214675, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PPP1R86, Protein phosphatase 1 regulatory subunit 86, Quinine 3-monooxygenase, SCAR13, Smp_128940, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, mGlu2, mGlu4, mGlu5, mGlu6, mGlu8, mGluR1, mGluR4, mGluR5, mGluR7
- FuncS
Unknown
Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)
SK-N-SH cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of (S)-3,5-DHPG (ab120007). Increased expression of CREB (phospho S133) in SK-N-SH cells correlates with an increase (S)-3,5-DHPG concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab32096 at 1/500 dilution and ab32515 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
- Chemical Structure
Lab
Chemical Structure - (S)-3,5-DHPG, group I mGlu agonist (AB120007)
2D chemical structure image of ab120007, (S)-3,5-DHPG, group I mGlu agonist
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Publications (30)
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iScience 26:108412 PubMed38053635
2023
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Nature communications 13:5272 PubMed36071061
2022
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Biology of reproduction 107:916-927 PubMed35746896
2022
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Cell reports 37:109805 PubMed34644573
2021
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Journal of neurochemistry 158:1094-1109 PubMed34327719
2021
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Function (Oxford, England) 2:zqab012 PubMed35330679
2021
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Cell reports 28:11-20.e9 PubMed31269433
2019
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Nature communications 8:1103 PubMed29062097
2017
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Scientific reports 6:28454 PubMed27345695
2016
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Frontiers in cellular neuroscience 9:367 PubMed26441538
2015
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