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MW 244.16 Da, Purity >98%. Broad spectrum agonist for AMPA and kainate receptors with no activity at NMDA or metabotropic receptors.

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Key facts

CAS number

21826-03-02

Purity

> 98%

Form

Solid

Molecular weight

244.16 Da

Molecular formula

C7H8N4O6

PubChem identifier

11096831

Nature

Synthetic

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Alternative names

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MW 244.16 Da, Purity >98%. Broad spectrum agonist for AMPA and kainate receptors with no activity at NMDA or metabotropic receptors.

Alternative names

Key facts

Purity

> 98%

PubChem identifier

11096831

Biochemical name

3-(5-Nitro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-L-Alanine

Biological description

Broad spectrum agonist for AMPA and kainate receptors with no activity at NMDA or metabotropic receptors

Canonical SMILES

C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)[N+](=O)[O-]

Isomeric SMILES

C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)[N+](=O)[O-]

InChI

InChI=1S/C7H8N4O6/c8-3(6(13)14)1-10-2-4(11(16)17)5(12)9-7(10)15/h2-3H,1,8H2,(H,13,14)(H,9,12,15)/t3-/m0/s1

InChIKey

IEBVITXSHAFLJR-VKHMYHEASA-N

IUPAC name

(2S)-2-amino-3-(5-nitro-2,4-dioxopyrimidin-1-yl)propanoic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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2 product images

  • Chemical Structure - (S)-5-Nitrowillardiine, AMPA / kainate agonist (ab120063), expandable thumbnail

    Chemical Structure - (S)-5-Nitrowillardiine, AMPA / kainate agonist (ab120063)

    2D chemical structure image of ab120063, (S)-5-Nitrowillardiine, AMPA / kainate agonist

  • Functional Studies - (S)-5-Nitrowillardiine, AMPA / kainate agonist (ab120063), expandable thumbnail

    Functional Studies - (S)-5-Nitrowillardiine, AMPA / kainate agonist (ab120063)

    ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with (S)-5-Nitrowillardiine (ab120063), by ICC/IF. Increase in MEK1 (phospho S298) expression correlates with increased concentration of (S)-5-Nitrowillardiine, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120063 ((S)-5-Nitrowillardiine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

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Product protocols

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