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MW 431.5 Da, Purity >98%. Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor (IC50 = 41 - 400 nM). (R)-DRF053 (ab141505) analog. More potent than roscovirtine. Apoptosis inducer. GSK-3α/β (glycogen synthase kinase-3α/β) inhibitor. Antitumor potential.

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Images

Chemical Structure - (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor (AB144231), expandable thumbnail

Publications

Key facts

CAS number
1084893-56-0
Purity
> 98%
Form
Solid
Molecular weight
431.5 Da
Molecular formula
C24H29N7O
PubChem identifier
25211051
Nature
Synthetic

Target data

Alternative names

DYR1A_HUMAN, DYRK, DYRK 1, DYRKA, Dual specificity YAK 1 related kinase, Dual specificity YAK1-related kinase, Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A, Dual specificity tyrosine phosphorylation regulated kinase, Dual specificity tyrosine phosphorylation regulated kinase 1, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, HP 86, MNB, MNB protein kinase, MNB protein kinase, Serine/threonine-specific, MNB/DYRK protein kinase, MNBH, MRD7, Minibrain (Drosophila) homolog, Minibrain homolog, Minibrain, Drosophila, homolog of, Mnb protein kinase homolog hp86, OTTHUMP00000109090, OTTHUMP00000109091, OTTHUMP00000109094, OTTHUMP00000174799, Protein kinase minibrain homolog, Serine/threonine kinase MNB, hMNB

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MW 431.5 Da, Purity >98%. Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor (IC50 = 41 - 400 nM). (R)-DRF053 (ab141505) analog. More potent than roscovirtine. Apoptosis inducer. GSK-3α/β (glycogen synthase kinase-3α/β) inhibitor. Antitumor potential.

See similar compound.

Key facts

Purity
> 98%
PubChem identifier
25211051
Solubility

Soluble in ethanol to 25 mM.

Soluble in DMSO to 10 mM.

Biochemical name
(2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol
Biological description

Potent, selective, cell-permeable cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor (IC50 = 41 - 400 nM). (R)-DRF053 (ab141505) analog. More potent than roscovirtine. Apoptosis inducer. GSK-3α/β (glycogen synthase kinase-3α/β) inhibitor. Antitumor potential.

See similar compound

Canonical SMILES
CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4
Isomeric SMILES
CC[C@@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4
InChI
InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30)/t19-/m0/s1
InChIKey
HOCBJBNQIQQQGT-IBGZPJMESA-N
IUPAC name
(2S)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor (ab144231), expandable thumbnail

    Chemical Structure - (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor (ab144231)

    2D chemical structure image of ab144231, (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor

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Product protocols

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